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  "documentTitle": "Soleno Therapeutics (SLNO)",
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      "text": "I’m concerned about the edema...heart arrhythmia, muscle spasms, and seizures.",
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      "text": "Highly concerned about cardiac risk due to edema. Q: \"So, you think this could potentially present cardiac risk in a quarter of patients?\" A: \"Cardiac is a big muscle, isn't it? It can. Right? Potassium, yeah...\"",
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      "text": "Concern about edema, compounded by diuretics; \"heart arrhythmia, muscle spasms, and seizures\" \"Therefore, it's going to certainly impact how you regulate your sodium, potassium, and magnesium in your body...\"",
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      "text": "“...interference with potassium, sodium, calcium, magnesium – all these...keep the heart functioning normally...that’s why I said I wanted to hold off [on Vykat]...and see what happens”; “low magnesium can cause seizures or muscle spasms or heart irregularity...I can see that could be a problem...when you’re on a diuretic...you’re losing your potassium... yes. I’m concerned about the edema...heart arrhythmia, muscle spasms, and seizures.” — Trial investigator and physician; one of the leading KOL’s in the PWS field",
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      "text": "Source: Scorpion Capital consultation calls with experts",
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      "text": "Diuretics in the context of PWS may exacerbate cardiac events and cause neurological ones like seizures, according to one of the most prominent, published, and influential authorities in the field",
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