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      "text": "fluid restriction. Experts recommend the use of a diuretic in every patient who receives diazoxide to prevent the effects of cardiorespiratory fluid overload;15 however, the use of diuretics was selective involving only four of our patients. In the group of patients who developed SAEs, three of eight patients received diuretics throughout the period of time that they developed respiratory deterioration and fluid overload. However, they did not show any signs of improvement until the diazoxide was discontinued. In addition, similar to findings from the existing literature, the development of edema was not dose dependent.15",
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      "text": "Soleno may have fleeced the FDA into a label that doesn't require concomitant diuretics, but its drug reps are being more transparent in sales meetings in recent weeks. Physicians we interviewed indicate being shocked, having thought that edema may be a transient feature, when reps suggested permanent diuretic therapy and gave them handouts for families to take home to recognize warning signs of edema. Unfortunately, diuretics are insufficient and cause severe secondary risks of their own. We again quote the previous paper: “three of eight patients received diuretics throughout the period of time that they developed respiratory deterioration and fluid overload...however, they did not show any signs of improvement until the diazoxide was discontinued...in addition, similar to findings from the existing literature, the development of edema was not dose dependent.”",
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      "text": "three of eight patients received diuretics throughout the period of time that they developed respiratory deterioration and fluid overload...however, they did not show any signs of improvement until the diazoxide was discontinued...in addition, similar to findings from the existing literature, the development of edema was not dose dependent.",
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      "text": "The danger of diazoxide in the neonatal intensive care unit",
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