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  "documentTitle": "Soleno Therapeutics (SLNO)",
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  "authorName": "Scorpion Capital",
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  "presentationDate": "2025-08-15 00:00:00",
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  "notes": "Uses expert quotes to debunk the necessity of the company's proprietary drug formulation.",
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      "text": "Endocrinologists indicated the argument was nonsense and that regular diazoxide can be dosed once a day for PWS as well – that they're all well-aware that diazoxide has a long half-life, so it achieves the same steady-state plasma level within days without need for extended-release.",
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      "text": "Liquid diazoxide is vastly superior to Vykat tablet; misconception that liquid diazoxide needs to be dosed 2-3X per day;",
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      "text": "Diazoxide already has a long half-life; only need once a day dosing for older kids with liquid; generic liquid is substitutable",
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      "text": "Generic liquid diazoxide is “always going to be better” than Vykat tablet; no need to give liquid 2-3X a day for PWS",
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      "kind": "quote",
      "text": "“I don't really know why a drug that's targeted at children would ever be a tablet because it's a nightmare. [...] I don't know why they've picked a tablet over a suspension.”",
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      "kind": "quote",
      "text": "“Yeah, a suspension is always going to be better. And I didn't appreciate it was going to be so expensive.” ... “Yeah, they should be. For Prader-Willi, I don't think you'd need to worry so much about titrating it...\"",
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      "text": "“...it does last. I know it's got a long half-life... Could we just use diazoxide instead of this very expensive Vykat? That's probably true.”",
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      "text": "Yeah, a suspension is always going to be better. And I didn't appreciate it was going to be so expensive. [...] I think even if, say, they were on the same oral suspension and you were worried about peak levels or whatever, you still wouldn't really need to give it two to three times daily, I don't think, because it's a different. — Trial investigator, pediatric endocrinologist; I don't really know why a drug that's targeted at children would ever be a tablet because it's a nightmare. [...] I don't know why they've picked a tablet over a suspension. And I guess they say it's because you need to give the suspension two to three times daily. But again, I think they're referring to what we do in hyperinsulinism, which is a very different condition. And we're giving that medicine because we want the sugars to be kept within a certain range, whereas in Prader-Willi Syndrome, managing the hyperphagia, it doesn't need to be done in that similar way. — Trial investigator, pediatric endocrinologist; ...it does last. I know it's got a long half-life, although we routinely prescribe it 2-3 times a day, I know as a child is older — the babies need more but as a child is older, once a day and even when they come off it, it takes a week or even two weeks before you see the kind of effects of diazoxide wearing off. I know it's got a long half-life. Could we just use diazoxide instead of this very expensive Vykat? That's probably true. My management will ask, \"Well, fine. You have no other drug? Okay. We can use it. — Trial investigator, key opinion leader for PWS",
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      "text": "Source: Scorpion Capital consultation calls with experts",
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      "text": "Soleno asserts that its extended-release tablet only needs to be dosed once daily versus Proglycem suspension 2-3X/day. Endocrinologists indicated the argument was nonsense and that regular diazoxide can be dosed once a day for PWS as well",
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