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  "documentTitle": "Soleno Therapeutics (SLNO)",
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      "text": "Not surprisingly, trial investigators and other endocrinologists across our interviews dismissed Vykat as just re-packaged diazoxide; indicated they would just prescribe Proglycem or generic suspension off-label if they wanted to use it in PWS.",
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      "text": "Not surprisingly, trial investigators and other endocrinologists across our interviews dismissed Vykat as just re-packaged diazoxide; indicated they would just prescribe Proglycem or generic suspension off-label if they wanted to use it in PWS; and expressed considerable skepticism of Soleno’s rationale for Vykat vs. regular diazoxide as lacking in credibility. As examples, we paste comments from the two different endocrinologists below, from the chapters on investigator and physician interviews – one was a study investigator.",
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      "text": "Extensive experience with generic diazoxide; unconvinced that Vykat extended release formulation adds any value. Diazoxide I use regularly... I'm not convinced whether it's the actual choline... or whether, is it really just the diazoxide?",
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      "text": "No reason to not use generic diazoxide suspension vs. Vykat; highly skeptical of arguments for Vykat vs. generic. ...this is the thing that is really a big question in my mind... Why wouldn't I just be prescribing diazoxide?",
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      "text": "“...this is the thing that is really a big question in my mind, because I don't really understand why — I haven't gotten a good answer, I don't feel like — why extended-release is necessary for this mechanism of action. And I feel cynically or realistically, that they're marketing an extended-release to get a different drug so they can get the patent. Why wouldn't I just be prescribing diazoxide?” — Pediatric endocrinologist, leads one of the largest PWS clinics in US with 30-40 patients; 11 endocrinologists, major academic center. “Diazoxide I use regularly...I am familiar with diazoxide, and I have been using it for many years. I normally give 2-3 times a day, and there is a liquid preparation. There are capsules. Although the liquid preparation, which is more stable...I suppose the question — is it worth the difference? [...] it's probably just the diazoxide, where the extended release probably makes no difference at all [...] I'm not convinced whether it's the actual choline, the extended choline release that makes a big difference, or whether, is it really just the diazoxide?” — Trial investigator, endocrinologist, key opinion leader for PWS",
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      "text": "Source: Scorpion Capital consultation calls with experts",
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