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  "documentTitle": "Soleno Therapeutics (SLNO)",
  "authorId": "58_Scorpion_Capital",
  "authorName": "Scorpion Capital",
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  "sourceTypeLabel": "Short seller",
  "presentationDate": "2025-08-15 00:00:00",
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  "notes": "The slide uses molecular weight calculations to expose that DCCR is simply a salt form of diazoxide, implying the price premium is unjustified.",
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      "kind": "callout",
      "text": "They are pharmacologically identical, but marketed with obfuscated dosing units and for price-gouging purposes only.",
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      "text": "DCCR (diazoxide choline controlled-release) is a salt form of diazoxide, specifically diazoxide choline, which combines diazoxide (the active drug) with choline (a counterion to form the salt). Molecular Weights: Diazoxide (C8H7ClN2O2S): ~230.67 g/mol Choline (C5H14NO): ~104.17 g/mol Diazoxide choline (1:1 salt): ~334.84 g/mol To find the % of diazoxide in diazoxide choline: [(230.67) x (104.17)] x 100 = 68.9% Approximately 69% of DCCR is actual diazoxide by weight; the remaining ~31% is the choline salt portion Proglycem is 100% diazoxide To calculate dose-equivalents for Proglycem: [(mg dose DCCR) x (0.689)] = mg dose Proglycem",
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      "kind": "paragraph",
      "text": "Circulating DCCR and Proglycem deliver identical molecular forms of diazoxide. They are pharmacologically identical, but marketed with obfuscated dosing units and for price-gouging purposes only. There is no difference in the circulating form, and no meaningful difference in pharmacokinetics (AUC, half-life, or mean residence time) when bioavailability is held constant. Simply put, only 69% of DCCR’s stated weight is diazoxide. Thus, mg Proglycem = mg DCCR x 0.69.",
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      "kind": "source-note",
      "text": "Source: Scorpion Capital analysis and estimates",
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      "kind": "table",
      "text": "DCCR mg dose | Proglycem mg Dose | Combination of DCCR tablets | Proglycem, dose (µL)*",
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      "kind": "title",
      "text": "DCCR tablets and regular diazoxide suspension are substitutable whether off-label Proglycem or generic - it is trivial to create a dosing conversion table using the molecular weights of diazoxide, choline, and diazoxide choline.",
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      "kind": "title",
      "text": "Dosing conversion table – Vykat tablet to regular diazoxide suspension",
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