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  "documentTitle": "Soleno Therapeutics (SLNO)",
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  "notes": "The slide uses a direct quote from the Pediatric Endocrine Society guidelines to expose the company's failure to address known side effects in their trial design.",
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      "text": "The problem for Soleno: a combination trial of its tablet and diuretics would have made the risk of PH/CHF obvious and killed its chances, not to mention scaring off physicians and parents.",
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      "text": "Source: https://academic.oup.com/jcem/article/105/12/3750/5894029",
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      "text": "Given that diazoxide mechanistically induces fluid retention, the Pediatric Endocrine Society practice guidelines (2020) “strongly recommend that a thiazide diuretic be started concomitantly with the initiation of diazoxide due to risk of fluid retention and PH” – “twice a day”; “higher doses may be required” - as well as restricting fluid intake. The problem for Soleno: a combination trial of its tablet and diuretics would have made the risk of PH/CHF obvious and killed its chances, not to mention scaring off physicians and parents.",
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      "text": "VII. Fluid management with diazoxide initiation: Thiazide use: We strongly recommend that a thiazide diuretic be started concomitantly with the initiation of diazoxide due to risk of fluid retention and PH. Fluid restriction: We suggest limiting fluid rate...",
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      "text": "Management and Appropriate Use of Diazoxide in Infants and Children with Hyperinsulinism",
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