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  "documentTitle": "Soleno Therapeutics (SLNO)",
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  "authorName": "Scorpion Capital",
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  "presentationDate": "2025-08-15 00:00:00",
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  "notes": "The slide uses direct excerpts from a medical paper to build a case against the drug's safety profile.",
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      "text": "Diazoxide toxicity is well-known in the literature – paper excerpts",
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      "text": "adverse outcome rate: 53%",
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      "text": "The incidence of PH after the use of diazoxide is reported to be from 2.4% to 7% by studies from larger institutions or subspecialty institutes where HH infants are more commonly managed.14,15 However, in our study population, 33% (5/15) of patients developed PH while 40% (6/15) of total patients developed respiratory failure. Our population-",
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      "text": "Pulmonary hypertension (PH) is a major serious adverse event recently identified with diazoxide use in infants. After the reported cases illustrating the severity of drug-dependent PH, the FDA issued a black box warning for diazoxide use and advised close monitoring in infants at risk of PH; mainly neonates with meconium aspiration syndrome, respiratory distress syndrome, transient tachypnea, pneumonia, sepsis, congenital diaphragmatic hernia or congenital cardiac disease.13,18 Since then, evidence in the literature describing severe pulmonary and cardiac adverse effects of diazoxide has been growing, indicating the incidence of PH is more common than previously thought. However, the supportive published studies are mainly institutional case series and case reports.11 In our study, there were more",
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      "text": "Ten minutes on PubMed/PubChem is all it takes to realize that unleashing diazoxide from a hospital setting into the general population is asking for trouble – in other words, don’t try this at home. VYKAT XR is merely a tablet version of diazoxide – an IP ploy - even more reckless for reasons we’ll get to. We examine the 2021 paper on the previous page, which reviewed safety outcomes over a 5-year period at a regional Midwest hospital. They used diazoxide for 15 infants with persistent hypoglycemia – 53% had an adverse outcome requiring diazoxide discontinuation; “40% of our patients deteriorated and then required mechanical ventilation”; “six of eight patients required intubation…five out of eight developed pulmonary hypertension.” The authors clearly wrote the paper because they think the literature is sparse and vastly understates the danger, indicating pulmonary hypertension in 2-7% of cases vs. their experience of 33% with PH and 40% with respiratory failure.",
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      "text": "“40% of our patients deteriorated and then required mechanical ventilation”; “six of eight patients required intubation…five out of eight developed pulmonary hypertension.” — 2021 paper on diazoxide safety outcomes",
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      "text": "Source: https://pmc.ncbi.nlm.nih.gov/articles/PMC8135194/pdf/10.1177_20420986211011338.pdf",
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      "text": "The danger of diazoxide in the neonatal intensive care unit",
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