{
  "docId": "019dd923-622c-750b-8b9a-3bcd52c6e583",
  "docSlug": "f06b0b5d2079",
  "documentTitle": "Soleno Therapeutics (SLNO)",
  "authorId": "58_Scorpion_Capital",
  "authorName": "Scorpion Capital",
  "documentKindSlug": "activist-deck",
  "documentKindLabel": "Activist deck",
  "sourceTypeSlug": "short_seller",
  "sourceTypeLabel": "Short seller",
  "presentationDate": "2025-08-15 00:00:00",
  "orientation": "landscape",
  "aspectRatio": 1.3333334,
  "pageNumber": 194,
  "pageCount": 415,
  "prevPage": 193,
  "nextPage": 195,
  "slideType": "expose_contradiction",
  "function": "expose_contradiction",
  "density": "balanced",
  "nDataPoints": 4,
  "notes": "Focuses on trial design bias and potential data suppression.",
  "elementsJson": [
    "headline_text",
    "bullet_list"
  ],
  "metadataConfidence": 1,
  "imagePath": null,
  "slideHref": "/slides/019dd923-622c-750b-8b9a-3bcd52c6e583/194",
  "deckHref": "/decks/019dd923-622c-750b-8b9a-3bcd52c6e583",
  "deckJsonHref": "/decks/019dd923-622c-750b-8b9a-3bcd52c6e583.json",
  "deckAnchorHref": "/decks/019dd923-622c-750b-8b9a-3bcd52c6e583#slide-194",
  "components": [
    {
      "bbox": null,
      "kind": "callout",
      "text": "This selective reporting suggests potential for data suppression or inconsistency",
      "attrs": null,
      "subkind": null,
      "toolName": "Visual emphasis",
      "toolSlug": "visual-emphasis",
      "confidence": null,
      "componentId": "019dd953-64ce-7561-b2a6-34c9006d4190",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.2,
        "w": 0.86,
        "x": 0.07,
        "y": 0.25
      },
      "kind": "list",
      "text": "Contradictory efficacy claims across trials: 7 points in 13 weeks (C601), 7 points in 3 years (OLE), 7 points in 4 months (RWP) with 50x higher response, 7-point change distributed across trial duration suggests time bias.",
      "attrs": null,
      "subkind": "bullet",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "3ae54592-7421-4234-8b8b-8c0533d43b12",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.35,
        "w": 0.86,
        "x": 0.07,
        "y": 0.48
      },
      "kind": "list",
      "text": "Failure to measure or report key biomarkers: Soleno measured only three (Leptin, adiponectin, acylated ghrelin), missing key hormones like PYY, PP, oxytocin, GLP-1. Ghrelin was only partially measured and dropped without explanation.",
      "attrs": null,
      "subkind": "bullet",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "f9cf54a5-2864-4dca-a499-d2eae9d998b4",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.03,
        "w": 0.25,
        "x": 0.07,
        "y": 0.95
      },
      "kind": "source-note",
      "text": "Source: Scorpion Capital analysis and estimates",
      "attrs": null,
      "subkind": null,
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "a53f16c6-e8eb-47d6-9505-d31de22777ec",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.15,
        "w": 0.86,
        "x": 0.07,
        "y": 0.07
      },
      "kind": "title",
      "text": "Red flags in clinical trials (cont'd) – we emphasize that the lack of robust biomarker data leaves HQ-CT behavioral outcomes uncorroborated, particularly in the RWP placebo-reversal study, where biomarker confirmation could have validated or refuted subjective observations; potentially an intentional strategy to obscure negative or non-significant findings.",
      "attrs": null,
      "subkind": "headline",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "04edd1a1-a67f-44ce-8d8e-856ba09ca5c3",
      "frameworkName": null,
      "frameworkSlug": null
    }
  ],
  "metrics": [],
  "tools": [],
  "frameworks": [
    {
      "name": "fraud-exposure",
      "slug": null,
      "matchId": "8eb44d4f-a38d-404c-bff9-ac9fb29e4310",
      "evidence": "The slide explicitly argues that selective reporting and lack of biomarker data are intentional strategies to obscure negative findings.",
      "confidence": 0.9
    }
  ],
  "arcBeats": [],
  "loops": [],
  "imagePathAlt": null,
  "thumbSrc": null,
  "thumbSrcAlt": null,
  "locked": true
}