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  "documentTitle": "Soleno Therapeutics (SLNO)",
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  "authorName": "Scorpion Capital",
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  "presentationDate": "2025-08-15 00:00:00",
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      "text": "Invalid endpoints create illusion of efficacy with no valid endpoints left",
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      "text": "Primary endpoint HQ-CT exhibits a pharmacodynamically implausible DCCR relationship: No dose-response, No plasma level-response, Inconsistent time-response, All changes in placebo range.",
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      "text": "Invalid endpoints create illusion of efficacy with no valid endpoints left: HQ-CT, LBM, HOMA-IR, Ghrelin, Leptin/Adiponectin.",
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      "text": "Some our key lines of inquiry: 1) primary endpoint HQ-CT exhibits a pharmacodynamically implausible DCCR relationship; 2) invalid endpoints create illusion of efficacy with no valid endpoints left; 3) contradictory efficacy claims across trials; and 4) failure to report or measure key biomarkers.",
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      "text": "Source: Scorpion Capital analysis and estimates",
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      "text": "We note numerous other red flags in the trials, which we analyzed and documented in an extensive appendix which we were unable to proof by today.",
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