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  "documentTitle": "Soleno Therapeutics (SLNO)",
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      "text": "Trial was functionally unblinded due to hair growth and edema, as well as tablet smell; families were in touch via social media; impossible to blind",
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      "text": "Trial was functionally unblinded due to hair growth and edema, as well as tablet smell; families were in touch via social media; impossible to blind",
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      "text": "Investigators and ex-employees indicated the trials were functionally unblinded by obvious side effects, namely hypertrichosis (hairiness) and edema, as well as by the smell of DCCR tablets vs. placebo...",
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      "text": "The hair thing is really difficult and same with the edema because you can't control for that. And you can't obviously give a placebo that would potentially make them have increased hair growth. It's difficult with this kind of study because you'll never be able to blind that properly.",
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      "text": "There were three main side effects which not everybody gets. I want to say about 15% may have had the side effect of edema and maybe 20% the side effect of hyperglycemia and maybe 20% the side effect of hypertrichosis. There certainly was potential for unblinding. No question..",
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      "text": "The smell was mentioned by one of them. The other, they were both males, they had a bit of hair growth...most of the patients in our group are on social media and the family forums and stuff.",
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      "text": "\"the hair thing is really difficult and same with the edema...you'll never be able to blind that properly\"; \"the smell was mentioned by one of them...patients in our group are on social media and the family forums and stuff.\" \"there certainly was potential for unblinding...no question.\" — Trial investigators",
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      "text": "Source: Scorpion Capital consultation calls with experts",
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