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  "documentTitle": "Soleno Therapeutics (SLNO)",
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  "presentationDate": "2025-08-15 00:00:00",
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      "text": "HQ-CT score is unreliable and subjective; baseline scores were unusually high and unclear if a “true genuine score”; questioning whether the decline from an inflated score is due to placebo effect",
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      "text": "HQ-CT score is not “very good”; hard to measure hyperphagia; “possible to manipulate it”",
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      "text": "Soleno’s trial investigators broadly repudiated HQ-CT as an outcome measure, as detailed in interview chapters, indicating that: parents exaggerated scores to meet HQ-CT inclusion criteria, with scores clustering around the entry threshold.",
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      "text": "as detailed in interview chapters, indicating that: parents exaggerated scores to meet HQ-CT inclusion criteria, with scores clustering around the entry threshold; that the average baseline score (22.6 in phase 3) sharply exceeded the 10.3 average per PWS population studies (n=400); that scores could fluctuate >30% weekly based on which parent did the survey. We quote two investigators whose comments were representative: “any kind of score like that...possible to manipulate it”; “skewed if they have overexaggerated” baseline scores; “perception of hyperphagia is a tricky one to quantify”; “the HQ-CT score, it’s not a great marker...it’s a subjective score...whether it’s the mom, dad, or grandparents”; “the median score of 20, that’s a very high score...most of my patients are nowhere near that...is it just placebo effect goes down for the score from 23 down to 15...is that really the drug?”",
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      "text": "“The other fundamental issue is actually the HQ-CT score. It’s not a great marker. It’s the only tool that we have as validated. But it’s not perfect. You’re basing a lot of your study or your analysis on something that’s not perfect. It’s not like your HbA1c or your cholesterol level. It’s a subjective score. It’s not a hard and fast measurement...it will vary depending on who’s done it, whether it’s the mom, the dad, or grandparents. In terms of the median score of 20, that’s a very high score. And most of my patients are nowhere near that. Now, whether that’s a true genuine score or not, I don’t know...If they’ve got such a high score, is it just purely a placebo effect goes down for the score from 23 down to 15, is that really the drug? Is that placebo? Is that the fact that they’ve done a trial? I don’t know.” -Trial investigator, endocrinologist, key opinion leader for PWS",
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      "text": "“I don’t think the HQ-CT score is very good, if I’m honest, because I think sometimes the perception of appearance and the level of hyperphagia is different to, say, another caregiver with the same child. So, in a school setting and so on. And it’s hard to know because maybe the child is able to manage or maybe mask some of the hyperphagia. I wouldn’t have thought so in the Prader-Willi Syndrome population, that they should have the ability to do that. But maybe somehow they know in certain settings what they can get away with. But I would say maybe perception of hyperphagia; it is a tricky one to quantify. And I think that’s the difficulty with these studies is what is genuine hyperphagia...I think the problem with any kind of score like that is it is possible to manipulate it.” -Trial investigator, pediatric endocrinologist",
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      "text": "\"I don't think the HQ-CT score is very good, if I'm honest, because I think sometimes the perception of appearance and the level of hyperphagia is different to, say, another caregiver with the same child... it is possible to manipulate it.\" — Trial investigator, pediatric endocrinologist; \"The other fundamental issue is actually the HQ-CT score. It's not a great marker... It's a subjective score... it will vary depending on who's done it, whether it's the mom, the dad, or grandparents... If they've got such a high score, is it just purely a placebo effect goes down for the score from 23 down to 15, is that really the drug?\" — Trial investigator, endocrinologist, key opinion leader for PWS",
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      "text": "Source: Scorpion Capital consultation calls with experts",
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      "text": "Soleno’s trial investigators broadly repudiated HQ-CT as an outcome measure",
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