{ "docId": "019dd923-622c-750b-8b9a-3bcd52c6e583", "docSlug": "f06b0b5d2079", "documentTitle": "Soleno Therapeutics (SLNO)", "authorId": "58_Scorpion_Capital", "authorName": "Scorpion Capital", "documentKindSlug": "activist-deck", "documentKindLabel": "Activist deck", "sourceTypeSlug": "short_seller", "sourceTypeLabel": "Short seller", "presentationDate": "2025-08-15 00:00:00", "orientation": "landscape", "aspectRatio": 1.3333334, "pageNumber": 189, "pageCount": 415, "prevPage": 188, "nextPage": 190, "slideType": "testimonial", "function": "expose_contradiction", "density": "overcrowded", "nDataPoints": 0, "notes": "The slide uses a Q&A format to present qualitative evidence of investigator misconduct.", "elementsJson": [ "paragraph", "quote_block", "footnote" ], "metadataConfidence": 1, "imagePath": null, "slideHref": "/slides/019dd923-622c-750b-8b9a-3bcd52c6e583/189", "deckHref": "/decks/019dd923-622c-750b-8b9a-3bcd52c6e583", "deckJsonHref": "/decks/019dd923-622c-750b-8b9a-3bcd52c6e583.json", "deckAnchorHref": "/decks/019dd923-622c-750b-8b9a-3bcd52c6e583#slide-189", "components": [ { "bbox": null, "kind": "callout", "text": "I think, in terms of senior leadership, I think they felt their hands were bound to some extent because she had enrolled so many patients.", "attrs": null, "subkind": null, "toolName": "Visual emphasis", "toolSlug": "visual-emphasis", "confidence": null, "componentId": "019dd953-64ce-7561-b2a6-1e589842e182", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.02, "w": 0.45, "x": 0.07, "y": 0.68 }, "kind": "paragraph", "text": "Soleno employees “mistrusted” Miller’s behavior during the trial", "attrs": null, "subkind": "paragraph", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "8b8fe84f-2a2a-4685-b4a4-463fe4ddfbda", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.02, "w": 0.35, "x": 0.07, "y": 0.45 }, "kind": "paragraph", "text": "Miller’s behavior troubled Soleno’s employees", "attrs": null, "subkind": "paragraph", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "9dff9d7c-9bc4-4d54-b947-ce933329a2b5", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.18, "w": 0.86, "x": 0.07, "y": 0.48 }, "kind": "quote", "text": "Q: “Did you ever observe anything around the investigators' conduct of the trial? Data manipulation, those kinds of red flags? Things that management had been asking you to do?” A: “I’m hesitant to describe this. I would say there is an investigator that I felt just behaved very strangely with regards to her patients and is very determined to get as many patients as possible into the study. I wouldn’t say she went as far as to — I think all of her patients met the criteria, but I have doubts around her assessment of global improvement. And, I think she really wanted to believe that this drug was helping these patients and was very gung-ho in an almost non-biased way.” Q: “I presume you're talking about Jennifer Miller.” A: “Yeah.” - Ex-senior Soleno employee #2, oversight of clinical trial program", "attrs": null, "subkind": "testimonial", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "343add96-f145-4e4a-ac7f-70d7c4015d10", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.18, "w": 0.86, "x": 0.07, "y": 0.71 }, "kind": "quote", "text": "Q: “Were there any people at Soleno that were kind of looking the other way, or sort of cooperating with her?” A: “I really mistrusted her, and it was very frustrating. I think other people found her exasperating for sure within the company, particularly on the operations side. I think, in terms of senior leadership, I think they felt their hands were bound to some extent because she had enrolled so many patients. And I can't speak beyond that. She was the primary, the most prolific enroller. You're trying to conclude a Phase 3 study, and it's very difficult to meet your enrollment numbers, and you're that far in.” - Ex-senior Soleno employee #2, oversight of clinical trial program", "attrs": null, "subkind": "testimonial", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "c3f4f155-d59a-4701-abdb-b963c9b2fc72", "frameworkName": null, "frameworkSlug": null }, { "bbox": null, "kind": "quote", "text": "I'm hesitant to describe this...I would say there is an investigator that I felt just behaved very strangely with regards to her patients and is very determined to get as many patients as possible into the study...I have doubts around her assessment of global improvement...very gung-ho in an almost non-biased way...I really mistrusted her, and it was very frustrating...I think other people found her exasperating for sure within the company...in terms of senior leadership, I think they felt their hands were bound...she was the primary, the most prolific enroller. — Ex-senior Soleno employee #2, oversight of clinical trial program", "attrs": null, "subkind": null, "toolName": "Authority citation", "toolSlug": "authority-citation", "confidence": null, "componentId": "019dd953-64ce-7561-b2a6-20271193d04a", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.02, "w": 0.3, "x": 0.07, "y": 0.95 }, "kind": "source-note", "text": "Source: Scorpion Capital consultation calls with experts", "attrs": { "numbered": true }, "subkind": null, "toolName": null, "toolSlug": null, "confidence": null, "componentId": "41830de5-8a37-4502-9f96-23de8b27c87f", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.35, "w": 0.86, "x": 0.07, "y": 0.07 }, "kind": "title", "text": "A third ex-employee, when we asked if any trial investigators engaged in questionable conduct, detailed similar concerns about Miller: “I’m hesitant to describe this…I would say there is an investigator that I felt just behaved very strangely with regards to her patients and is very determined to get as many patients as possible into the study…I have doubts around her assessment of global improvement…very gung-ho in an almost non-biased way”; “I really mistrusted her, and it was very frustrating…I think other people found her exasperating for sure within the company…in terms of senior leadership, I think they felt their hands were bound…she was the primary, the most prolific enroller.”", "attrs": null, "subkind": "headline", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "efe98c11-7df0-4c2b-8d4d-03c1ca7ea033", "frameworkName": null, "frameworkSlug": null } ], "metrics": [], "tools": [], "frameworks": [], "arcBeats": [], "loops": [], "imagePathAlt": null, "thumbSrc": null, "thumbSrcAlt": null, "locked": true }