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  "documentTitle": "Soleno Therapeutics (SLNO)",
  "authorId": "58_Scorpion_Capital",
  "authorName": "Scorpion Capital",
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  "presentationDate": "2025-08-15 00:00:00",
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  "notes": "The slide uses a specific Facebook post as a case study to contradict the product's efficacy claims.",
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      "text": "The key, devastating takeaway from the FB group: in the last few weeks, the 4 posts with the most engagement and largest number of comments – by orders of magnitude – are sharply negative.",
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      "text": "The tone in the primary VYKAT group was ambivalent to negative during May/June but has turned sharply negative in recent weeks. The general ratio of negative/ambivalent comments to positive ones suggests to us that Soleno’s launch may already be close to hitting a wall, as the initial bolus of desperate parents willing to try anything dries up. The sporadic positive comments strike us as tepid with clear placebo bias – parents reporting a “positive” hyperphagia effect are prone to sentiments like it took 18 months before they noticed benefit and that they still have to keep the food locked up. The key, devastating takeaway from the FB group: in the last few weeks, the 4 posts with the most engagement and largest number of comments – by orders of magnitude – are sharply negative. Shockingly, the post where we see the most comments – 61 as of late last week – is about VYKAT *increasing* hyperphagia, with parents piling on to complain.",
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      "kind": "quote",
      "text": "My son is 9 and we're on week 12 of VYKAT. We're seeing a huge increase in hyperphasia. Anyone else?",
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      "text": "Source: Facebook groups – “Vykat discussion group” https://www.facebook.com/share/g/17JomVRpoV/?mibextid=wwXlfr; “Vykat for PWS: Evidence, Experience, & Encouragement” https://www.facebook.com/share/g/14HMwkfXhzm/?mibextid=wwXlfr",
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