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  "notes": "The slide uses direct quotes from pediatric endocrinologists to highlight safety concerns, specifically referencing the drug's potential to exacerbate existing cardiac risks in PWS patients.",
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      "text": "Investigator #6, for example, stated extreme concern about cardiac events, based on extensive experience using diazoxide for hyperinsulinism – “in the other condition we use diazoxide for, pulmonary edema is a massive concern of ours...the main adverse event that I would be worried about with this drug and the potential for that...difficult to predict who will develop that...personally, I would always be ordering echos on any child before and during treatment.”",
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      "text": "Investigator #6, for example, stated extreme concern about cardiac events, based on extensive experience using diazoxide for hyperinsulinism...",
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      "text": "Well, this is the thing.— what we know with Prader-Willi is they're likely to have problems with their left ventricular function, probably as a result of obesity and blood pressure trending higher and things like that.",
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      "text": "Certainly, in the other condition we use diazoxide for, pulmonary edema is a massive concern of ours. We use it in babies, and we need to make sure that the children have all had echos before they go on it and at regular intervals afterwards.",
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      "text": "“Certainly, in the other condition we use diazoxide for, pulmonary edema is a massive concern of ours. We use it in babies, and we need to make sure that the children have all had echos before they go on it and at regular intervals afterwards. That, I guess, would be the main adverse event that I would be worried about with this drug and the potential for that. And what we have found is that it's difficult to predict who will develop that. I don't know enough about the UK case to be able to comment on its own, but that is the adverse event that would make me kind of make sure that I've explained that to the family, that there is that risk. And personally, I would always be ordering echos on any child before and during treatment with diazoxide.” — Trial investigator, pediatric endocrinologist",
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