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  "documentTitle": "Soleno Therapeutics (SLNO)",
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  "presentationDate": "2025-08-15 00:00:00",
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  "notes": "The slide uses expert testimony to highlight a potential safety concern (edema) and suggests the company is downplaying or managing it in an unusual way.",
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      "text": "\"Serious cardiac events\" and \"pulmonary edema\"; skeptical/concerned about Soleno rep's answer to questions about pulmonary edema; \"permanent edema\"; handout to recognize edema",
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      "text": "Soleno’s handout suggests significant concern about edema",
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      "text": "\"We do get Echos in all babies. \"Usually, we get a before echo, and then we'll typically get one a couple of weeks later. If that's okay, we don't do them every two weeks or consistently unless we're always talking about changes in respiration or things like that. As far as serious cardiac events, we did talk about pulmonary edema at the visit, and she even said something about giving people a handout and how to recognize edema. And I was just like, \"huh!\" I would expect something transient, but I wouldn't expect a permanent edema, to be honest...\" - Pediatric endocrinologist at an academic center with eight endocrinologists and ~50 PWS patients",
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      "text": "\"as far as serious cardiac events, we did talk about pulmonary edema at the visit, and she even said something about giving people a handout and how to recognize edema...and I was just like, \"huh!\" I would expect something transient, but I wouldn't expect a permanent edema, to be honest\"; \"they said something about...teaching people how to recognize the edema at home, which, I'm an endocrinologist, and I can certainly do that, pitting versus not...but that's not something we're typically do.\"",
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      "text": "Q: \"Is that what the rep hinted at? They were worried enough about edema that they gave a handout?\"\nA: \"Yes. They said something about the families are very good and teaching people how to recognize the edema at home, which, I'm an endocrinologist, and I can certainly do that, pitting versus not. But that's not something we're typically do.\" - Pediatric endocrinologist at an academic center with eight endocrinologists and ~50 PWS patients",
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      "text": "“as far as serious cardiac events, we did talk about pulmonary edema at the visit, and she even said something about giving people a handout and how to recognize edema...and I was just like, \"huh!\" I would expect something transient, but I wouldn't expect a permanent edema, to be honest” — Pediatric endocrinologist at an academic center with eight endocrinologists and ~50 PWS patients",
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      "text": "Source: Scorpion Capital consultation calls with experts",
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