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  "documentTitle": "Soleno Therapeutics (SLNO)",
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  "authorName": "Scorpion Capital",
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  "presentationDate": "2025-08-15 00:00:00",
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  "notes": "The slide uses a technical explanation of DEXA limitations to undermine the company's reported clinical trial results.",
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      "text": "3 key body composition claims (LBM, fat mass, BMI) are invalidated by DEXA artifact, undermining efficacy assertions.",
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      "text": "DEXA scan diagram",
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      "text": "DCCR is known to cause fluid retention... DEXA cannot distinguish muscle from water... Reported increases in LBM (2-7 kg)... Temporal pattern aligns... Fat mass decreases were short-lived... Soleno never properly disclosed... 3 key body composition claims...",
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      "text": "DEXA (dual-energy X-ray absorptiometry) is widely used to assess body composition, but it has important limitations and artifacts, particularly when interpreting lean body mass (LBM). A major concern is overestimation of LBM in the presence of fluid retention, including edema, overhydration, or inflammatory swelling. DEXA cannot distinguish muscle from water: both are attenuated similarly by X-rays.",
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      "text": "Source: Scorpion Capital analysis and estimates",
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