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  "documentTitle": "Soleno Therapeutics (SLNO)",
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  "authorName": "Scorpion Capital",
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  "presentationDate": "2025-08-15 00:00:00",
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  "notes": "The slide uses a medical illustration to show the impact of fluid retention on heart chambers (diastolic vs systolic).",
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      "text": "Since PWS are already at high risk for cardiovascular disease, this mechanism-based fluid retention caused by VYKAT XR is of particular concern in this sensitized population",
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      "text": "Medical diagram showing Diastolic (stiff/thick chambers, heart can't fill) and Systolic (stretched/thin chambers, heart can't pump) heart states.",
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      "text": "Excess extracellular fluid increases venous return to the heart. The heart must work harder to pump the excess venous volume leading to thickened walls of the ventricles called cardiac hypertrophy. The heart cannot effectively pump the extra volume of blood (reduced ejection fraction). DCCR is indicated for long-term treatment in PWS leading to chronic fluid retention that could lead to heart failure (particularly congestive heart failure). Since PWS are already at high risk for cardiovascular disease, this mechanism-based fluid retention caused by VYKAT XR is of particular concern in this sensitized population.",
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      "text": "Source: Scorpion Capital analysis and estimates",
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      "text": "Edema may impair cardiac function resulting in heart failure.",
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      "text": "How fluid retention can precipitate congestive heart failure",
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