{
  "docId": "019dd923-622c-750b-8b9a-3bcd52c6e583",
  "docSlug": "f06b0b5d2079",
  "documentTitle": "Soleno Therapeutics (SLNO)",
  "authorId": "58_Scorpion_Capital",
  "authorName": "Scorpion Capital",
  "documentKindSlug": "activist-deck",
  "documentKindLabel": "Activist deck",
  "sourceTypeSlug": "short_seller",
  "sourceTypeLabel": "Short seller",
  "presentationDate": "2025-08-15 00:00:00",
  "orientation": "landscape",
  "aspectRatio": 1.3333334,
  "pageNumber": 142,
  "pageCount": 415,
  "prevPage": 141,
  "nextPage": 143,
  "slideType": "expose_contradiction",
  "function": "expose_contradiction",
  "density": "dense",
  "nDataPoints": 0,
  "notes": "The slide uses medical definitions to frame the clinical trial results as evidence of adverse effects (edema) related to the drug DCCR.",
  "elementsJson": [
    "paragraph",
    "photo"
  ],
  "metadataConfidence": 0.9,
  "imagePath": null,
  "slideHref": "/slides/019dd923-622c-750b-8b9a-3bcd52c6e583/142",
  "deckHref": "/decks/019dd923-622c-750b-8b9a-3bcd52c6e583",
  "deckJsonHref": "/decks/019dd923-622c-750b-8b9a-3bcd52c6e583.json",
  "deckAnchorHref": "/decks/019dd923-622c-750b-8b9a-3bcd52c6e583#slide-142",
  "components": [
    {
      "bbox": {
        "h": 0.06,
        "w": 0.6,
        "x": 0.07,
        "y": 0.29
      },
      "kind": "callout",
      "text": "Clinical manifestations of diazoxide-induced edema (volume overload) reported in Phase 3 trial include pulmonary edema",
      "attrs": null,
      "subkind": "primary",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "cec9d300-b4cf-4ae6-a7d6-db569c84dc24",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.15,
        "w": 0.25,
        "x": 0.7,
        "y": 0.35
      },
      "kind": "image",
      "text": "Peripheral edema",
      "attrs": null,
      "subkind": "photo",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "8455bd17-3483-4dc2-b945-af4238146f1a",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.15,
        "w": 0.25,
        "x": 0.7,
        "y": 0.75
      },
      "kind": "image",
      "text": "Periorbital edema",
      "attrs": null,
      "subkind": "photo",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "b312953e-6068-4572-aeb3-5e59750489c3",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.15,
        "w": 0.25,
        "x": 0.7,
        "y": 0.55
      },
      "kind": "image",
      "text": "Facial edema",
      "attrs": null,
      "subkind": "photo",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "cc1d1fb0-87a8-4364-9dc6-b97488f803a7",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.45,
        "w": 0.6,
        "x": 0.07,
        "y": 0.38
      },
      "kind": "list",
      "text": "Peripheral edema – the swelling of tissues usually in the legs, ankles and feet caused by the accumulation of fluid in the interstitial space\nFacial edema – the swelling of the face due to excess fluid accumulation under the skin\nPeriorbital edema – swelling around the eyes, especially the eye sockets due to fluid accumulation under the skin. The eyes have loose connective tissue making them especially prone\nImpaired cardiac function that may lead to pulmonary edema\nOver time this can lead to hypertension and cardiac tissue remodeling in patients with PWS → congestive heart failure\nPeripheral edema, facial edema, periorbital edema and pulmonary edema reported in clinical trials conducted by Soleno with DCCR",
      "attrs": null,
      "subkind": "bullet",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "ca2c2fb0-8334-4a57-8355-97f25f228eeb",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.15,
        "w": 0.6,
        "x": 0.07,
        "y": 0.07
      },
      "kind": "paragraph",
      "text": "Pulmonary edema is the accumulation of fluid in the lung tissue and air spaces (alveoli), typically due to left heart failure or fluid overload, causing increased hydrostatic pressure that forces fluid out of the pulmonary capillaries into the lungs. When fluid overload exceeds the heart’s capacity to pump, left heart strain or pre-existing cardiac issues tip the balance toward pulmonary edema.",
      "attrs": null,
      "subkind": "paragraph",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "5ad579ac-3f77-4ce2-a463-520bdab706d6",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.05,
        "w": 0.6,
        "x": 0.07,
        "y": 0.92
      },
      "kind": "source-note",
      "text": "Source: Scorpion Capital analysis and estimates; https://en.wikipedia.org/wiki/Edema; https://doi.org/10.3390/reports4030022; https://en.wikipedia.org/wiki/Periorbital_puffiness",
      "attrs": null,
      "subkind": null,
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "449e1bb0-a4d1-4baf-862c-213ed215d121",
      "frameworkName": null,
      "frameworkSlug": null
    }
  ],
  "metrics": [],
  "tools": [],
  "frameworks": [],
  "arcBeats": [],
  "loops": [],
  "imagePathAlt": null,
  "thumbSrc": null,
  "thumbSrcAlt": null,
  "locked": true
}