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  "documentTitle": "Soleno Therapeutics (SLNO)",
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  "authorName": "Scorpion Capital",
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  "presentationDate": "2025-08-15 00:00:00",
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      "text": "Patients with PWS are more susceptible to heart failure, edema, and oxygen desaturation",
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      "text": "Risk Factor 1: Extreme Obesity that begins in early childhood predisposing patients to hypertension, atherosclerosis, cardiomyopathy and obstructive sleep apnea\nRisk Factor 2: Hypotonia and low physical activity due to muscle weakness and fatigue with a reduced ability to exercise\nRisk Factor 3: The sedentary lifestyle worsens insulin resistance and fat accumulation\nRisk Factor 4: Dyslipidemia – elevated triglycerides, low HDL and sometimes high LDL cholesterol are seen in PWS and tend to develop earlier\nRisk Factor 5: Growth hormone deficiency is typical in PWS leading to increased fat mass, lean body mass, lipid dysregulation and lower cardiac output and stroke volume\nRisk Factor 6: Sleep apnea (common in PWS) leads to hypoventilation reduced oxygen to heart tissue",
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      "text": "Clinical signs of edema (facial, peripheral, periorbital) were reported across the trials and conflated to mask true incidence. PWS patients are uniquely vulnerable due to obesity, OSA, hypotonia, low cardiac reserve, and GH deficiency. Chronic fluid overload may lead to eccentric hypertrophy, HFpEF (heart failure with preserved ejection fraction), and salt-sensitive hypertension.",
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      "text": "Source: Scorpion Capital analysis and estimates",
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      "text": "Pulmonary edema, a serious adverse event, is buried in the AE tables, with no transparent reporting or discussion in the publications.",
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