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  "documentTitle": "Soleno Therapeutics (SLNO)",
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      "text": "2017 paper – perhaps the most cited on growth hormone's diabetogenic profile",
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      "text": "Growth hormone’s diabetogenic action is well-known in the scientific literature: “One study demonstrated 2–6 times higher incidence of diabetes mellitus than expected in the normal general population”.",
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      "text": "Growth hormone (GH) is important for promotion of somatic growth and the regulation of substrate metabolism. Metabolic action of GH occurs in multiple tissues including the liver, muscle, fat and pancreas either directly or indirectly through insulin-like growth factor 1. The diabetogenic action of GH has been well-described in previous in vivo studies. In this paper, we review the metabolic effects of GH on peripheral tissues focusing on glucose metabolism and insulin resistance, and discuss results from human studies on the long-term effects of GH administration on insulin resistance and hyperglycemia. determined yet. International cohort studies indicate that GH therapy may increase the incidence of type 2 diabetes mellitus in children and adolescents with predisposing risk factors, therefore it is prudent to monitor possible negative consequences on glucose metabolism during and after GH administration. Large-scale longitudinal cohort studies are",
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      "text": "Growth hormone's diabetogenic action is well-known in the scientific literature: “One study demonstrated 2–6 times higher incidence of diabetes mellitus than expected in the normal general population”; “international cohort studies indicate that GH therapy may increase the incidence of type 2 diabetes mellitus in children and adolescents with predisposing risk factors, therefore it is prudent to monitor possible negative consequences on glucose metabolism during and after GH administration.”",
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      "text": "“One study demonstrated 2–6 times higher incidence of diabetes mellitus than expected in the normal general population”; “international cohort studies indicate that GH therapy may increase the incidence of type 2 diabetes mellitus in children and adolescents with predisposing risk factors, therefore it is prudent to monitor possible negative consequences on glucose metabolism during and after GH administration.” — Effects of growth hormone on glucose metabolism and insulin resistance in human (2017 paper)",
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