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  "documentTitle": "Soleno Therapeutics (SLNO)",
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  "presentationDate": "2025-08-15 00:00:00",
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  "notes": "The slide uses a line chart to demonstrate that the fasting glucose values are identical to a previous study (Miller et al 2024), implying the new HbA1c claims are fabricated.",
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      "text": "Since Soleno appears to have forgotten to change the fasting glucose graph from the original dataset, we can calculate associated HbA1c values - which suggests to us that the new HbA1c numbers are simply made up to fit a misleading narrative that entry ITT were already prediabetic.",
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      "text": "MEAN (SE) FASTING GLUCOSE OVER TIME",
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      "text": "HbA1c = (FG+46.7)/28.7. The HbA1c values in red were calculated from the fasting glucose values in the new Shoemaker et al (2025) presentation, which are identical to the fasting glucose values in the original Miller et al (2024) poster. Soleno also split up the figure and placed another slide in between which makes the changes less obvious.",
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      "text": "HbA1c = (FG+46.7)/28.7. The HbA1c values in red were calculated from the fasting glucose values in the new Shoemaker et al (2025) presentation, which are identical to the fasting glucose values in the original Miller et al (2024) poster.",
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      "text": "Source: https://investors.soleno.life/presentations/scientific-posters-presentations; https://investors.soleno.life/static-files/7c732b67-56dc-4959-ac2f-31543a7c0ca3; Scorpion Capital analysis and estimates",
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      "text": "Since Soleno appears to have forgotten to change the fasting glucose graph from the original dataset, we can calculate associated HbA1c values - which suggests to us that the new HbA1c numbers are simply made up to fit a misleading narrative that entry ITT were already prediabetic.",
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