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  "documentTitle": "Soleno Therapeutics (SLNO)",
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      "text": "Soleno claimed normalization of DCCR-driven HbA1c elevation after 65 weeks of treatment; the single timepoint they cited is an outlier favoring their reversal narrative but not representative of the entire dataset and the progressive nature of glucose dysregulation by DCCR.",
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      "text": "HbA1c variance: p<0.01",
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      "text": "HbA1c variance (SD) increase linearly with DCCR treatment duration (p=0.011)\nThis means that DCCR causes a steady decline in glucose homeostasis and increase in pre-T2D and T2D\nSoleno claimed normalization of DCCR-driven HbA1c elevation after 65 weeks of treatment; the single timepoint they cited is an outlier favoring their reversal narrative but not representative of the entire dataset and the progressive nature of glucose dysregulation by DCCR.\nSoleno later (July 2025 Shoemaker et al presentation) shortens the standard deviations (variance) of the entire treatment timecourse making them equivalent to hide the existence of DCCR-driven metabolic toxicity as well as its progressive nature.",
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      "text": "Soleno later (July 2025 Shoemaker et al presentation) shortens the standard deviations (variance) of the entire treatment timecourse making them equivalent to hide the existence of DCCR-driven metabolic toxicity as well as its progressive nature.",
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      "text": "Source: Scorpion Capital estimates and analysis",
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      "text": "Analysis of OLE dataset",
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