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  "documentTitle": "Soleno Therapeutics (SLNO)",
  "authorId": "58_Scorpion_Capital",
  "authorName": "Scorpion Capital",
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  "sourceTypeLabel": "Short seller",
  "presentationDate": "2025-08-15 00:00:00",
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  "notes": "The slide uses red arrows and dots to visually demonstrate the discrepancy between cited data and the actual study graph.",
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      "kind": "callout",
      "text": "The two data HbA1c data points - highlighted again in red/yellow – are above all of the points in their own time series.",
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      "kind": "chart",
      "text": "FIGURE 1: Mean Hemoglobin A1C (%) by Week of DCCR Administration",
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      "kind": "chart",
      "text": "FIGURE 2: Mean Fasting Plasma Glucose (mg/dL) by Week of DCCR Administration",
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      "text": "Figure 2: Fasting Glucose (mg/dL) Baseline (~Week 0): ~89–90 mg/dL Week 13 & 26: ~95–98 mg/dL Week 78: ~91 mg/dL Week 104–156: ~92–94 mg/dL",
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      "text": "Figure 1: HbA1c (%) Baseline (~Week 0): ~4.9–5.0% Peaks at Week 13 & 26: ~5.2–5.25% Lowest at Week 78: ~5.0% Never returns to baseline Week 156: HbA1c remains elevated (~5.2%)",
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      "text": "HbA1c levels",
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      "text": "The HbA1c data set cited here is published in the May 4, 2024 poster by Gevers, Miller et al, analyzed earlier in this section. The two data HbA1c data points - highlighted again in red/yellow – are above all of the points in their own time series.",
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      "kind": "quote",
      "text": "\"HbA1c followed a similar pattern, being elevated at 26 Weeks (Change from Baseline mean±SD 0.19±0.50%) and returned nearly to baseline by 65 Weeks (Baseline mean±SD 5.547%±0.4069%; 65 weeks 5.572%±0.5103%).\" — Phase 3 open-label study paper - Miller et al (2024), excerpt",
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      "text": "Source: https://pubmed.ncbi.nlm.nih.gov/37919617/; https://investors.soleno.life/static-files/27318113-e299-408f-ba14-0b05114f37bc; Scorpion Capital estimates and analysis",
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      "kind": "title",
      "text": "The two HbA1c data points cherry-picked in the Miller et al (2024) open-label publication are arbitrary and do not show a recovery to baseline – in fact, the data points appear to conjured out of thin air.",
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