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  "documentTitle": "Soleno Therapeutics (SLNO)",
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  "authorName": "Scorpion Capital",
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  "presentationDate": "2025-08-15 00:00:00",
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  "notes": "The slide uses a red box and arrow to draw attention to the increase in HbA1c between week 0 and week 13.",
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      "text": "Note that the pooled week-13 mean HbA1c is higher than baseline and unexpectedly elevated, even though it is comprised of 1/3 placebo patients suggesting the hidden DCCR mean is even higher.",
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      "text": "Note that the pooled week-13 mean HbA1c is higher than baseline and unexpectedly elevated, even though it is comprised of 1/3 placebo patients suggesting the hidden DCCR mean is even higher. Separately, the poster has no discussion of this critical HbA1c chart and glosses over it with a single sentence: “Longitudinal mean fasting glucose (FG) and HbA1c increased slightly over the initial 6-9 months but stabilized or returned to near-baseline levels upon continued DCCR dosing (Figure 1 and Figure 2)” – which as we shall demonstrate is contradicted by Soleno’s own data.",
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      "text": "“Longitudinal mean fasting glucose (FG) and HbA1c increased slightly over the initial 6-9 months but stabilized or returned to near-baseline levels upon continued DCCR dosing (Figure 1 and Figure 2)” — Gevers, Miller et al (May 16, 2024 poster).",
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      "text": "May 16, 2024 poster by Gevers, Miller et al – Soleno website",
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      "text": "Source: https://investors.soleno.life/static-files/27318113-e299-408f-ba14-0b05114f37bc",
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      "text": "FIGURE 1: Mean Hemoglobin A1C (%) by Week of DCCR Administration",
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