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  "documentTitle": "Soleno Therapeutics (SLNO)",
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  "authorName": "Scorpion Capital",
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  "presentationDate": "2025-08-15 00:00:00",
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  "notes": "The slide uses a combination of narrative accusation and technical definitions to frame the company's data as obfuscated.",
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      "text": "Our analysis of the data buried in Soleno’s papers indicates an alarming spike in prediabetes and diabetes within 13 weeks of starting Vykat – and a linear increase over 3 years with no signs of a plateau.",
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      "text": "1. Hemoglobin A1c (HbA1c) Test\n- Reflects the average blood glucose over the prior 2 to 3 months, based on the glycation of red blood cell hemoglobin.\n- Prediabetes range: 5.7% to 6.4%\n- Diabetes range: >6.4%\n2. Fasting Plasma Glucose (FPG) Test\n- Measures blood glucose after at least 8 hours of fasting, typically overnight.\n- Prediabetes range: 100 to 125 mg/dL (5.6 to 6.9 mmol/L)\n- Diabetes range: >125 mg/dL\n3. Oral Glucose Tolerance Test (OGTT)\n- After fasting, the individual drinks a 75g glucose solution and blood glucose is measured 2 hours later.\n- Prediabetes range: 140 to 199 mg/dL (7.8 to 11.0 mmol/L) at the 2-hour mark\n- Diabetes range: >199 mg/dL",
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      "text": "Our analysis of the data buried in Soleno’s papers indicates an alarming spike in prediabetes and diabetes within 13 weeks of starting Vykat – and a linear increase over 3 years with no signs of a plateau. The papers obfuscate the danger and exhibit troubling irregularities. Only two Soleno publications contain meaningful data for prediabetes and diabetes-related (T2D) markers – we shortly examine each. Three primary tests are typically used for diagnosis: 1) hemoglobin A1C (HbA1c), with a prediabetes range of 5.7% to 6.4% and >6.4% for diabetes; 2) fasting plasma glucose (FPG) test, with a prediabetes range of 100-125 mg/dL (5.6-6.9 mmol/L) and >125 mg/dL for diabetes; and 3) oral glucose tolerance test (OGTT) with a prediabetes range of 140-199 mg/dL and >199 mg/dL for diabetes.",
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      "text": "Source: ADA/NIH publications",
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      "text": "Diagnostic measures of prediabetes and diabetes",
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