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      "text": "JNJ looked at same molecular structures as pitolisant, with the same piperidine ring btu with better chemistry; Bioprojet didn't look at many structures; just borrowed from another academic and “stuck with the first compound they've got”; didn't even seem to know its pharmacokinetics",
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      "text": "Bioprojet “just stuck with the first compound that they got” – suggesting that Bioprojet didn’t even properly understand their own molecule vs. J&J which “did a hell a lot of chemistry around the templates we had.”",
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      "text": "The scientist was intimately familiar with Bioprojet’s history with pitolisant and was dismissive, stating they just appropriated a stale compound from someone else: “I don’t think those guys looked at tons of structures, to be honest. I think that's a pretty old structure.” He stated that in contrast to J&J which tested hundreds of compounds, that Bioprojet “just stuck with the first compound that they got” – suggesting that Bioprojet didn’t even properly understand their own molecule vs. J&J which “did a hell a lot of chemistry around the templates we had.” He indicated that his team at J&J had independently developed compounds with the same molecular structure as pitolisant – defined by a piperidine ring – and viewed it as an inferior molecule.",
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      "text": "A: “I don’t think those guys looked at tons of structures, to be honest. I think that's a pretty old structure. My thought was that those structures—a lot of that stuff came from a guy called Robin Ganellin at University College London. And what he was looking for, it's got a chlorophenyl group in it, is my recollection. There was a whole series of histamine H3 antagonists that came out of this big group, which was UCL, Free University of Berlin, and another, and they had admitted it was all base compounds. So, they started with histamine and their focus was to look for replacements for the imidazole ring. So that whole chlorophenyl-propoxy piece, I believe, was in an older H3 antagonist, which had an imidazole ring, so it was based on histamine. What they did is they looked, and they just simply replaced the imidazole ring with a heterocycle, which I recall was piperidine.”\nQ: “Yeah, it's piperidine. But is there anything that the piperidine ring gives them that everybody else struggled with?”\nA: “Yeah, we had a core piperidine in some of them. The key to what we did, which other people recognized afterwards, was what controls the length of time it stays in the body to a large extent is the basicity of the piperidine ring. And what we published was that if you lower the PKA, which is the degree of basicity of that nitrogen, you can control the pharmacokinetics. And that was the key to the molecule we had. We published all this. It's in a paper. And that gave us the pharmacokinetic profile that we were looking for. We drove the basicity down. We did a hell a lot of chemistry around the templates we had. And you could add that piperidine ring—it can be a bigger ring; it can't be a smaller ring. So, I think they just stuck with the first compound they've got.” –Longtime senior scientist at Johnson & Johnson, with global leadership roles in neuroscience",
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      "text": "“I don't think those guys looked at tons of structures, to be honest. I think that's a pretty old structure.” — Longtime senior scientist at Johnson & Johnson, with global leadership roles in neuroscience",
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      "text": "Source: Scorpion Capital consultation calls with experts",
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