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  "documentTitle": "Harmony Biosciences (HRMY)",
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      "text": "We know this is unsolvable...we just gave up.",
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      "text": "The ex-Abbott scientist stated they actually synthesized pitolisant and tested it as a comparator, and that it had the same fatal flaws as H3 receptor candidates they developed internally: “they didn’t solve the problem, and we didn’t solve the problem.”",
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      "text": "He said that because of Abbott’s history with histamine-based drugs like betahistine that “we know this is unsolvable...we just gave up,” noting that this is “an area where there a lot of products failing one after another” due to toxicity and other issues.",
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      "text": "He indicated that pitolisant exhibited the same lack of bioavailability; that “the variability was very similar to our compound”; and that “we didn’t see much of it passing the blood-brain barrier...I remember it was around 3-4%, something in that range maximum, with very high variability.”",
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      "text": "“they didn't solve the problem, and we didn't solve the problem.” — Senior pharmaceutical executive/scientist, previously at Abbott and now at another major pharma company",
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      "text": "Source: Scorpion Capital consultation calls with experts",
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