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      "text": "2019 paper by a longtime collaborator of Bioprojet's head, Jean-Charles Schwartz",
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      "text": "It is in fact difficult to find a major player that *not* attempt an H3 program and fail, as the list of flops includes those by Pfizer, Merck, Astra Zeneca, Johnson & Johnson/Janssen, Abbott, Glaxo Smith Kline, Novartis, Sanofi, and Schering-Plough.",
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      "text": "Since the discovery of the histamine H3 receptor in 1983, tremendous advances in the pharmacological aspects of H3 receptor antagonists/inverse agonists have been accomplished in preclinical studies. At present, there are several drug candidates...",
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      "text": "starting with thioperamide's synthesis in 1987 and termination due to hepatic and other liabilities. Our review of the clinical literature indicates that virtually every global pharma company had an active H3 ligand development effort...",
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      "text": "obstacles in developing these agents are emphasized — 2019 paper by a longtime collaborator of Bioprojet's head, Jean-Charles Schwartz",
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      "text": "Histamine H3 receptor antagonists/inverse agonists: Where do they go?",
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