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  "documentTitle": "Harmony Biosciences (HRMY)",
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      "text": "Tellingly, he stated that \"drug companies remained essentially uninterested in this research.\"",
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      "text": "Schwartz appears to have tested hundreds if not thousands of potential H3 receptor ligands, going back to the 1990's. He even wrote a paper in 2010 documenting the challenges, noting one compound after another that failed due to toxicity or other reasons. He stated that thioperamide was the first H3-receptor compound, developed in 1987, but it “displayed hepatoxicity.” Then Bioprojet developed ciproxifan “which had to be abandoned after toxicity tests performed by Bioprojet.” Tellingly, he stated that “drug companies remained essentially uninterested in this research.”",
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      "text": "\"displayed hepatoxicity.\" — Jean-Charles Schwartz (2010 paper). \"which had to be abandoned after toxicity tests performed by Bioprojet.\" — Jean-Charles Schwartz (2010 paper). \"drug companies remained essentially uninterested in this research.\" — Jean-Charles Schwartz (2010 paper).",
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      "text": "Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3111674/?report=classic",
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      "text": "The long and twisted timeline of pitolisant papers and trials is damning, suggesting that Bioprojet was well aware of its myriad dangers and flaws and rejected it as their lead H3 candidate multiple times over a decade.",
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      "text": "The histamine H3 receptor: from discovery to clinical trials with pitolisant",
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