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  "documentTitle": "Harmony Biosciences (HRMY)",
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      "text": "Jean-Charles Schwartz paper submitted for publication in 2001 - table shows same molecule as pitolisant",
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      "text": "We unearthed a Schwartz paper from 2001 that includes a table with H3 receptor candidates, including a molecule then named FUB 649 – which we noticed is identical to pitolisant – which of course also means it’s too old to have any intellectual property protection left.",
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      "text": "Chemical structures and comparison of FUB 649 and pitolisant",
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      "text": "Harmony licensed pitolisant from a small lab in France called Bioprojet. Our investigation reveals Bioprojet’s multi-decade attempt to develop a histamine H3 receptor drug, resulting in one utter failure after another – including pitolisant.",
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      "text": "From our review of every paper published by Jean-Charles Schwartz going back to the 1990's, we were startled to discover that pitolisant is an ancient compound, first synthesized a quarter-century ago. We unearthed a Schwartz paper from 2001 that includes a table with H3 receptor candidates, including a molecule then named FUB 649 – which we noticed is identical to pitolisant – which of course also means it’s too old to have any intellectual property protection left.",
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      "text": "Development of a New Class of Nonimidazole Histamine H3 Receptor Ligands with Combined Inhibitory Histamine N-Methyltransferase Activity — Joachim Apelt, Xavier Ligneau, Heinz H. Pertz, Jean-Michel Arrang, C. Robin Ganellin, Jean-Charles Schwartz, Walter Schunack and Holger Stark.",
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      "text": "Source: https://pubmed.ncbi.nlm.nih.gov/11855993/",
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