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      "text": "Piperidines and piperazines are great structures, and medicinal chemistry would be a lot poorer without them, but they can set off hERG activity, which can (in some cases) lead to heart rhythm problems, which can (in pretty much all cases) lead to your drug wiping out.",
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      "text": "Another Funny-Looking Structure Comes Through\nthat piperidine is the polar add-on, but it turned out to be more trouble than it was worth...",
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      "text": "“turned out to be more trouble than it was worth” and that it “can set off hERG activity, which can (in some cases) lead to hearth rhythm problems, which can (in pretty much all cases) lead to your drug wiping out. And maybe taking you with it....” – “everyone would be worried about what might happen when the stuff hit the general population.” — Science (blog post)",
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