{ "docId": "019dd923-622c-750b-8b9a-21918ac10c17", "docSlug": "f3db2294dcf9", "documentTitle": "Harmony Biosciences (HRMY)", "authorId": "58_Scorpion_Capital", "authorName": "Scorpion Capital", "documentKindSlug": "research-note", "documentKindLabel": "Research note", "sourceTypeSlug": "short_seller", "sourceTypeLabel": "Short seller", "presentationDate": "2023-03-28 00:00:00", "orientation": "landscape", "aspectRatio": 1.3333334, "pageNumber": 38, "pageCount": 366, "prevPage": 37, "nextPage": 39, "slideType": "expose_contradiction", "function": "expose_contradiction", "density": "dense", "nDataPoints": 0, "notes": "The slide uses a combination of summary text and a direct testimonial quote to establish a pattern of behavior.", "elementsJson": [ "paragraph", "quote_block" ], "metadataConfidence": 0.9, "imagePath": null, "slideHref": "/slides/019dd923-622c-750b-8b9a-21918ac10c17/38", "deckHref": "/decks/019dd923-622c-750b-8b9a-21918ac10c17", "deckJsonHref": "/decks/019dd923-622c-750b-8b9a-21918ac10c17.json", "deckAnchorHref": "/decks/019dd923-622c-750b-8b9a-21918ac10c17#slide-38", "components": [ { "bbox": null, "kind": "callout", "text": "He described him as paranoid and “getting into screaming matches” and “shouting matches” with scientists at international meetings – “he did it to somebody from Novo Nordisk”; “he attacked a guy from GSK…it’s just insane.”", "attrs": null, "subkind": null, "toolName": "Visual emphasis", "toolSlug": "visual-emphasis", "confidence": null, "componentId": "019dd953-64d0-7099-9ccc-b66ea962768a", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.15, "w": 0.86, "x": 0.07, "y": 0.07 }, "kind": "paragraph", "text": "Harmony licensed pitolisant from a French lab called Bioprojet, run by an idiosyncratic scientist named Jean-Charles Schwartz, who spent decades hunting for an H3 drug like Captain Ahab after Moby Dick, with little to show for it until Jeff Aronin showed up.", "attrs": null, "subkind": "paragraph", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "d12fe238-de02-4ae0-96a9-051f6a68984f", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.35, "w": 0.86, "x": 0.07, "y": 0.22 }, "kind": "paragraph", "text": "We spoke with various sources who shared troubling anecdotes of his scientific approach and personal conduct. A European KOL called him “crazy,” but demurred when we asked for specifics. Others were more forthcoming, such as a scientist who spent decades at a global pharma company, publishing hundreds of papers including foundational work on the H3 receptor. His knowledge of pitolisant was in-depth, and he described his interactions with Schwartz - “an odd sort of guy” - and recounted a story of his shouting from the audience at presenters at conferences – “It was bizarre. I’d never come across that before.” He described him as paranoid and “getting into screaming matches” and “shouting matches” with scientists at international meetings – “he did it to somebody from Novo Nordisk”; “he attacked a guy from GSK…it’s just insane.”", "attrs": null, "subkind": "paragraph", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "f747c1ab-9c83-4587-9f41-789ea92f8490", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.3, "w": 0.86, "x": 0.07, "y": 0.63 }, "kind": "quote", "text": "“That would describe Jean-Charles. It was really fundamental research that he published. But then, after a while, it’s like, well, so what? It was a great discovery, but it doesn’t make you a pharmaceutical company, right? When I showed up, the first talk I gave was in the Netherlands on what we were doing…and at the end of the talk, he shouted from the audience. He said how can I have the nerve to come to Europe and not acknowledge all the work that they did? And I was just stealing all their science. He did that in a public forum. And he did it to somebody from Novo Nordisk, who was talking in the lecture before and then two years later, he attacked a guy from GSK. It’s just insane. And I’d never had this at a scientific meeting…there was a degree of arrogance there.. It was bizarre. I’d never come across that before…he was always very dismissive of other pharmaceutical companies, and I had a couple of shouting matches with him over some of the science because he felt he was the owner of H3. He had actually—he characterized the receptor. He got two nice papers in Nature, I believe. But he was a—I don’t want to be pejorative about—he had this arrogance about him… When pitolisant came out—I remember going to international meetings and getting into screaming matches with these guys because they felt they had everything and all the big pharma companies would rip them off, which was not the case—Ex-longtime senior scientist at Johnson & Johnson, with global leadership roles in neuroscience", "attrs": null, "subkind": "testimonial", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "de1dbf0f-59fb-4d51-bda7-8afda37a503c", "frameworkName": null, "frameworkSlug": null }, { "bbox": null, "kind": "quote", "text": "“That would describe Jean-Charles. It was really fundamental research that he published. But then, after a while, it’s like, well, what? It was a great discovery, but it doesn’t make you a pharmaceutical company, right? When I showed up, the first talk I gave was in the Netherlands on what we were doing…and at the end of the talk, he shouted from the audience. He said how can I have the nerve to come to Europe and not acknowledge all the work that they did? And I was just stealing all their science. He did that in a public forum. And he did it to somebody from Novo Nordisk, who was talking in the lecture before and then two years later, he attacked a guy from GSK. It’s just insane. And I’d never had this at a scientific meeting…there was a degree of arrogance there.. It was bizarre. I’ve never come across that before…he was always very dismissive of other pharmaceutical companies, and I had a couple of shouting matches with him over some of the science because he felt he was the owner of H3. He had actually—he characterized the receptor. He got two nice papers in Nature, I believe. But he was a—I don’t want to be pejorative about—he had this arrogance about him… When pitolisant came out—I remember going to international meetings and getting into screaming matches with these guys because they felt they had everything and all the big pharma companies would rip them off, which was not the case” — Ex-longtime senior scientist at Johnson & Johnson, with global leadership roles in neuroscience", "attrs": null, "subkind": null, "toolName": "Authority citation", "toolSlug": "authority-citation", "confidence": null, "componentId": "019dd953-64d0-7099-9ccc-ba6e71192d6b", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.02, "w": 0.3, "x": 0.07, "y": 0.95 }, "kind": "source-note", "text": "Source: Scorpion Capital consultation calls with experts", "attrs": null, "subkind": null, "toolName": null, "toolSlug": null, "confidence": null, "componentId": "f750659a-1573-467d-b1f9-d4edccfc3fae", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.03, "w": 0.25, "x": 0.07, "y": 0.59 }, "kind": "title", "text": "Anecdotes of Schwartz’s behavior", "attrs": null, "subkind": "subtitle", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "96c8c945-19e5-495c-985c-1e1d09daff11", "frameworkName": null, "frameworkSlug": null } ], "metrics": [], "tools": [], "frameworks": [], "arcBeats": [ { "to": 50, "from": 31, "beatId": "2b789ae4-940c-4d3a-9f03-7f2e7e4f46fd", "arcName": "Overcoming the Monster", "arcSlug": "overcoming-monster", "beatName": "The Struggle", "beatSlug": null, "evidence": "The document presents the struggle of the company's critics and short-sellers to expose the truth", "position": 2, "confidence": 0.8, "parentBeatName": null, "parentBeatSlug": null } ], "loops": [], "imagePathAlt": null, "thumbSrc": null, "thumbSrcAlt": null, "locked": true }