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      "text": "The concerns are detailed in the report we received, which include: 1) a failure to correct the H3 receptor antagonist radioligand (the foundation of the study) for metabolism, which artificially inflates the results; 2) troubling patterns in the data that \"call into question the accuracy of the information presented in the PET study.\"",
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      "text": "In order to concoct some evidence in man of pitolisant's purported mechanism of action, Bioprojet funded a 2020 PET brain imaging study (n=6 healthy adults) to show that the drug “produces a high occupancy of H3 receptors” in “nine brain regions of interest” – that is, that the drug binds to the H3 receptor. The study is as dubious as the bioavailability and CNS uptake data. Our pharmacology consultant engaged a longtime PET expert to review methodology and data, who has conducted identical studies, who found it so unusual as to state that he has “never seen data like this.” The concerns are detailed in the report we received, which include: 1) a failure to correct the H3 receptor antagonist radioligand (the foundation of the study) for metabolism, which artificially inflates the results; 2) troubling patterns in the data that “call into question the accuracy of the information presented in the PET study.”",
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      "text": "The fraction of active C11-GSK189254 was not corrected for metabolism... he has never seen data like this. This then calls into question the accuracy of the information presented in the PET study. He said he would never trust the accuracy of PET data beyond 45 min.",
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      "text": "he has never seen data like this. This then calls into question the accuracy of the information presented in the PET study. He said he would never trust the accuracy of PET data beyond 45 min. — PET expert consultant",
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