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  "documentTitle": "Harmony Biosciences (HRMY)",
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      "text": "The consultant’s review details a pattern of flagrant flaws that led to the “vastly overestimated bioavailability”",
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      "text": "The consultant's review details a pattern of flagrant flaws that led to the \"vastly overestimated bioavailability\": 1) the Bioprojet studies were plagued by a dubious methodology and errors... 2) Bioprojet's data shows that they knew the importance of correcting... 3) the human mass balance studies were equally suspect... and 4) the failure to conduct standard bioavailability assessments...",
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      "text": "The package insert for Pitolisant states that the absorption is >90% in human subjects... However, neither of these statements are correct since the concentration of metabolites were not accounted for... According to the EMA, the absolute bioavailability of Pitolisant \"has not been determined\"... There are numerous problems with the determination of F% by mass balance...",
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      "text": "According to the EMA, the absolute bioavailability of Pitolisant “has not been determined”. (EMA 2015, p 34). This is the correct statement.",
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      "text": "Source: Bioavailability analysis commissioned by Scorpion Capital",
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