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  "documentTitle": "Harmony Biosciences (HRMY)",
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  "notes": "The slide uses box-whisker plots to demonstrate a lack of correlation between histamine/metabolite levels and various sleep disorder etiologies.",
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      "text": "Bioprojet-funded paper shows no association between histamine (left) or its metabolite (right) with various etiologies of excessive daytime sleepiness such as narcolepsy with and without cataplexy an idiopathic hypersomnia",
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      "text": "Figure 3—CSF measurement of tele-methylhistamine (t-MHA) level",
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      "text": "Figure 2—CSF measurement of histamine (HA) level",
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      "text": "The paper never mentions “pitolisant” but acknowledges that it contradicts the Bioprojet clinical trials already conducted, and further admits that the results negate their starting “hypothesis” that “CSF HA [histamine] and t-MHA [histamine metabolite] were…interesting biological markers of EDS.” The paper adds that it supersedes a previous study that showed an association, as this one used a newer “ultra-sensitive, ultra-performance assay…for the simultaneous analysis of HA and its major stable metabolite tele-methylhistamine (t-MHA) in CSF.” The paper cites “recent data” in monkeys that similarly showed no correlation.",
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      "text": "The paper never mentions “pitolisant” but acknowledges that it contradicts the Bioprojet clinical trials already conducted, and further admits that the results negate their starting “hypothesis” that “CSF HA [histamine] and t-MHA [histamine metabolite] were...interesting biological markers of EDS.”",
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      "text": "Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3443762/pdf/aasm.35.10.1359.pdf",
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