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      "text": "Conclusion: CSF histamine and tele-methylhistamine did not significantly differ between patients with narcolepsy-cataplexy and other etiologies of non-hypocretin-1 deficient central hypersomnias; these measurements, therefore, are not useful in assessing the etiology or severity of centrally mediated hypersomnia.",
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      "text": "Measurements and Results: No between-hypersomnia group differences were found for CSF HA levels... No association was found between CSF HA, t-MHA, or HA + t-MHA, sleepiness, treatment intake, and frequency of cataplexy.",
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      "text": "Even if there was evidence that pitolisant increases histamine levels in the brain, it wouldn't matter as Bioprojet once published a study that unequivocally discredits the purported mechanism of action.",
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      "text": "Conclusion: CSF histamine and tele-methylhistamine did not significantly differ between patients with narcolepsy-cataplexy and other etiologies of non-hypocretin-1 deficient central hypersomnias; these measurements, therefore, are not useful in assessing the etiology or severity of centrally mediated hypersomnia. — Yves Dauvilliers et al., 2012",
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