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  "documentTitle": "Harmony Biosciences (HRMY)",
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  "notes": "The slide uses a 'fraud-exposure' approach by highlighting circular citations and methodological weaknesses in the foundational research.",
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      "text": "1991 Schwartz paper (at right) cited above merely cites rodent studies from the 1970’s and early 1980’s",
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      "text": "Our literature search going back decades failed to locate a single study demonstrating a correlation or index of histamine levels vs. t-meha, whether in rodents or humans.",
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      "text": "Chart of t-meha levels in mouse brain after oral administration of pitolisant, as % of control",
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      "text": "The red flags are numerous. First, both papers measure a histamine metabolite (T-meha) and not histamine, a questionable method with no evidence of its validity. One of these papers states that “t-meha levels [are] an index of histaminergic activity,” citing a 1991 paper by Schwartz, which we read and merely passes the buck by citing rodent studies from the 1970’s and early 1980’s. Our literature search going back decades failed to locate a single study demonstrating a correlation or index of histamine levels vs. t-meha, whether in rodents or humans.",
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      "text": "“t-meha levels [are] an index of histaminergic activity,” — Schwartz (1991)",
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      "text": "Source: https://pubmed.ncbi.nlm.nih.gov/17005916/; https://pubmed.ncbi.nlm.nih.gov/1846044/",
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      "text": "Comically, the entire claim that pitolisant increases histamine levels in the brain – the whole premise of its mechanism of action - is based on two dubious rodent studies from 2006 and 2007",
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