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      "text": "Laughed and said he couldn't say Wakix is any better than a placebo, and thinks competing drugs like oxybate class are stronger.",
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      "text": "Not even sure it's better than placebo; sodium oxybate is better\n\"Well, I think it was a little better [ESS score] reduction than that. But I'd have to go back. I haven't actually looked at those original papers for a couple of years now...well, I remember it was not much. My clinical impression is that when it comes to efficacy, oxybates are stronger, and the oxybate trials generally showed a better separation from placebo in this regard. The higher dose was like 9 grams of oxybate per night, separate really well from placebo, and pitolisant didn't, and that's why...I do think it's...[chuckles]...I would like to think it's better than placebo, but I'd have to say I can't say that numerically I have much data to support that beyond what's in published papers.\" - -Neurologist and professor at a pre-eminent academic institution, advisor to Harmony",
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      "text": "Large practice with >100 narcolepsy patients\n\"I'm a neurologist at a big Boston academic hospital. I only see sleep disorder patients, and my clinic is very skewed towards narcolepsy. I take care of more than 100 patients with narcolepsy. I also spend a lot of my time doing research on the basic mechanism through which drugs work in narcolepsy.\" -Neurologist and professor at a pre-eminent academic institution",
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      "text": "No better than generics like modafinil and worse than oxybates, so haven't used it in more than 10 patients; only a combo therapy\n\"I think pitolisant is a useful tool in our choice of medications that we use for treating narcolepsy. To really get to the bottom line, for what it delivers, I find it sort of annoyingly expensive. As a comparator, sodium oxybate and the low-sodium oxybate are also even more expensive, $150,000-plus per year. But they also can produce pretty high efficacy. Pitolisant is a well-tolerated drug, but its efficacy in my mind as far as treating sleepiness is not all that different than, say, modafinil. To be honest, I haven't actually used it in more than maybe 10 patients at this point. But my impression with most of them is that, yeah, it's helpful, but it doesn't really knock it out of the park. And so, I would say that's actually the biggest reason why I haven't prescribed it more is just because people say, yeah, it's okay, but they usually need something else on top of it...I can't think of a single patient where we've used Wakix as monotherapy.\" - -Neurologist and professor at a pre-eminent academic institution, advisor to Harmony",
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      "text": "I can't think of a single patient where we've used Wakix as monotherapy. It's almost always in combination with other meds. — Neurologist and professor at a pre-eminent academic institution, advisor to Harmony",
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      "text": "Source: Scorpion Capital consultation calls with experts",
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      "text": "Prescriber #14: Neurologist and professor at a pre-eminent medical school, medical advisor to Harmony with a long relationship with the company. Large narcolepsy practice with >100 patients but hasn't used Wakix in more than ~10 patients cumulatively: no better then generics like modafinil; \"doesn't really knock it out of the park\"; \"can't think of a single patient where we've used Wakix as monotherapy.\" Laughed and said he couldn't say Wakix is any better than a placebo, and thinks competing drugs like oxybate class are stronger.",
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