{
  "docId": "019dd923-622c-750b-8b9a-21918ac10c17",
  "docSlug": "f3db2294dcf9",
  "documentTitle": "Harmony Biosciences (HRMY)",
  "authorId": "58_Scorpion_Capital",
  "authorName": "Scorpion Capital",
  "documentKindSlug": "research-note",
  "documentKindLabel": "Research note",
  "sourceTypeSlug": "short_seller",
  "sourceTypeLabel": "Short seller",
  "presentationDate": "2023-03-28 00:00:00",
  "orientation": "landscape",
  "aspectRatio": 1.3333334,
  "pageNumber": 274,
  "pageCount": 366,
  "prevPage": 273,
  "nextPage": 275,
  "slideType": "nominee_bio",
  "function": "introduce_nominees",
  "density": "dense",
  "nDataPoints": 4,
  "notes": "The slide presents qualitative expert testimony regarding drug discontinuation rates.",
  "elementsJson": [
    "headline_text",
    "paragraph",
    "quote_block",
    "footnote"
  ],
  "metadataConfidence": 1,
  "imagePath": null,
  "slideHref": "/slides/019dd923-622c-750b-8b9a-21918ac10c17/274",
  "deckHref": "/decks/019dd923-622c-750b-8b9a-21918ac10c17",
  "deckJsonHref": "/decks/019dd923-622c-750b-8b9a-21918ac10c17.json",
  "deckAnchorHref": "/decks/019dd923-622c-750b-8b9a-21918ac10c17#slide-274",
  "components": [
    {
      "bbox": null,
      "kind": "callout",
      "text": "I want to say it's pretty high. It's about 25% to 30%. Again, it's not a drug that works right away, so a lot of these patients they're not de novo; they've been on drugs that work much more quickly, some of the SNRIs that we use, some of the amphetamines, things like that. You have to counsel patients. Maybe at two months, you might see a benefit, maybe three months. A lot of patients just don't want to stay on it.",
      "attrs": null,
      "subkind": null,
      "toolName": "Visual emphasis",
      "toolSlug": "visual-emphasis",
      "confidence": null,
      "componentId": "019dd953-70f3-714d-84c6-b8a1055492d9",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": null,
      "kind": "metric",
      "text": "discontinuation rate: 25% to 30%",
      "attrs": null,
      "subkind": "primary",
      "toolName": "Quantification",
      "toolSlug": "quantification",
      "confidence": null,
      "componentId": "019dd953-70f3-714d-84c6-c3e73c10cfc1",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.35,
        "w": 0.86,
        "x": 0.07,
        "y": 0.17
      },
      "kind": "paragraph",
      "text": "High discontinuation rate\nQ: \"Do you have a ballpark number in your head of what is the discontinuation rate that you've personally seen?\"\nA: \"I want to say it's pretty high. It's about 25% to 30%. Again, it's not a drug that works right away, so a lot of these patients they're not de novo; they've been on drugs that work much more quickly, some of the SNRIs that we use, some of the amphetamines, things like that. You have to counsel patients. Maybe at two months, you might see a benefit, maybe three months. A lot of patients just don't want to stay on it. This is a younger population for the most part. They're busy; they don't want to try new things. So, it's about 25% that say, \"It's not working. I felt better previously on something,\" or \"I want to discontinue and try XYZ instead.\" - Neurologist in the New York, major academic center",
      "attrs": null,
      "subkind": "paragraph",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "6d2e4e6d-005a-474b-bcf8-673805b23595",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": null,
      "kind": "quote",
      "text": "I want to say it's pretty high. It's about 25% to 30%. Again, it's not a drug that works right away, so a lot of these patients they're not de novo; they've been on drugs that work much more quickly, some of the SNRIs that we use, some of the amphetamines, things like that. You have to counsel patients. Maybe at two months, you might see a benefit, maybe three months. A lot of patients just don't want to stay on it. This is a younger population for the most part. They're busy; they don't want to try new things. So, it's about 25% that say, \"It's not working. I felt better previously on something,\" or \"I want to discontinue and try XYZ instead.\" — Neurologist in the New York, major academic center",
      "attrs": null,
      "subkind": null,
      "toolName": "Authority citation",
      "toolSlug": "authority-citation",
      "confidence": null,
      "componentId": "019dd953-70f3-714d-84c6-bfd91f80ad50",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.02,
        "w": 0.3,
        "x": 0.07,
        "y": 0.95
      },
      "kind": "source-note",
      "text": "Source: Scorpion Capital consultation calls with experts",
      "attrs": null,
      "subkind": null,
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "1348d8b1-73a9-4469-83ad-bf2bbdda2c05",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.07,
        "w": 0.86,
        "x": 0.07,
        "y": 0.07
      },
      "kind": "title",
      "text": "Prescriber #10: Neurologist in New York City at a leading medical center with 20 out of 100-120 narcolepsy patients on Wakix.",
      "attrs": null,
      "subkind": "headline",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "c1f9d398-b272-4d4f-b035-baed854a8dba",
      "frameworkName": null,
      "frameworkSlug": null
    }
  ],
  "metrics": [],
  "tools": [],
  "frameworks": [],
  "arcBeats": [],
  "loops": [],
  "imagePathAlt": null,
  "thumbSrc": null,
  "thumbSrcAlt": null,
  "locked": true
}