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  "documentTitle": "Harmony Biosciences (HRMY)",
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  "notes": "The slide uses a comparative analysis of clinical trial data to challenge the validity of the HARMONY 3 results.",
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      "text": "Thus, if we use the 1 month ESS reduction for placebo (-3.4) from HARMONY 1, the HARMONY 3 reduction was inferior (-3.37).",
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      "text": "Table 13: Summary of ESS Scores",
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      "text": "Even though the ESS reductions shown in HARMONY 3 are implausibly high given the number of efficacy-related withdrawals, they are still far lower than in HARMONY 1, 1-bis, and CTP to the point that they wouldn't have been statistically significant vs. placebo had this not been a single-arm trial.",
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      "text": "The ESS score, assessed at each visit, decreased along the 12-month period (Figure 3). Compared to baseline, the mean score (±SE) decreased from the first month of treatment (-3.37 ± 0.42; n = 93) and continued to decline after 3 (-4.39 ± 0.51) and 6 months (-4.90 ± 0.54).",
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      "text": "Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6802569/pdf/zsz174.pdf; https://www.accessdata.fda.gov/drugsatfda_docs/nda/2021/211150Orig2s000StatR.pdf; Scorpion Capital analysis and estimates",
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