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  "documentTitle": "Harmony Biosciences (HRMY)",
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  "authorName": "Scorpion Capital",
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  "presentationDate": "2023-03-28 00:00:00",
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  "notes": "The slide uses ClinicalTrials.gov record history to demonstrate a 'red flag' in trial reporting.",
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      "text": "The unexplained and arbitrary cut-off suggests an attempt to cherry-pick a favorable data interval.",
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      "text": "Outcome measures primary endpoint change detail",
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      "text": "The CTP trial was once again absurdly short with only a 7-week treatment duration, a week shorter than the brief 8 weeks in HARMONY 1 and 1-bis. The unexplained and arbitrary cut-off suggests an attempt to cherry-pick a favorable data interval.",
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      "text": "In particular, the primary endpoint seems to have been abruptly changed at the end of the trial – a striking red flag. The record history on ClinicalTrials.gov indicates that the original primary outcome measure was weekly cataplexy rate at week 49.",
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      "text": "Source: https://clinicaltrials.gov/ct2/history/NCT01800045?A=1&B=6&C=merged#StudyPageTop",
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