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  "documentTitle": "Harmony Biosciences (HRMY)",
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  "authorName": "Scorpion Capital",
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  "presentationDate": "2023-03-28 00:00:00",
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  "notes": "The author argues that the discrepancy hides a trend reversal that would undermine the trial's efficacy claims.",
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      "kind": "callout",
      "text": "Final ESS score in table is 12.0 while the chart shows ~10.7. The final value in the table is the mean of weeks 7 and 8 (visits 6 and 7). This suggests that the green line for pitolisant would be above 12 in either week 7 or 8, as 12 can only be the mean if one of those two values is >12.",
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      "text": "If the chart reflected the value in the table, which appears to be the correct one given multiple references in the paper, it would show a quick and sharp reversal of the pitolisant trend after week 3 (visit 5), undermining the results and necessitating data longer than 8 weeks, which the trials clearly try to avoid with the absurdly short duration.",
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      "text": "Figure 3: Changes in Epworth sleepiness scale (ESS) score",
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      "text": "ESS score: 12.0",
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      "text": "The values in the table and chart are consistent for baseline and final ESS scores for placebo and modafinil. The chart also correctly shows the baseline score for pitolisant. However, the final score for pitolisant in the table is 12.0, while the chart shows it as ~10.7 (visually estimated) for week 8 (visit 7). If the chart reflected the value in the table, which appears to be the correct one given multiple references in the paper, it would show a quick and sharp reversal of the pitolisant trend after week 3 (visit 5), undermining the results and necessitating data longer than 8 weeks, which the trials clearly try to avoid with the absurdly short duration.",
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      "text": "Source: https://pubmed.ncbi.nlm.nih.gov/24107292/; https://epworthsleepinessscale.com/about-the-ess/",
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      "text": "We further note troubling discrepancies between ESS scores in the summary data table vs. the all-important chart of ESS scores by week.",
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