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  "documentTitle": "Harmony Biosciences (HRMY)",
  "authorId": "58_Scorpion_Capital",
  "authorName": "Scorpion Capital",
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  "presentationDate": "2023-03-28 00:00:00",
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  "notes": "The slide uses a combination of narrative text and specific evidence (EMA table and ClinicalTrials.gov record) to prove the existence of a suppressed trial.",
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      "text": "Our research indicates a HARMONY 2 trial was in fact conducted - only to fail and be buried, with the oddly-named “1-bis” inserted in its place as “2” was taken.",
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      "text": "Harmony's clinical trials indicate a pattern of cherry-picking \"successful\" trials and burying the ones that undermine the drug. Of the ones published (HARMONY 1, CTP, and 3), the papers omit key data and we can find no record of an appendix or supplementary package with a full data set. However, those omissions pale next to failed phase 3 trials that are simply concealed. An astute reader may notice that Harmony's slide - and FDA submissions - show trials called HARMONY 1 and 3, but curiously no HARMONY 2. Our research indicates a HARMONY 2 trial was in fact conducted - only to fail and be buried, with the oddly-named \"1-bis\" inserted in its place as \"2\" was taken. We found another failed trial called HARMONY 4, also buried. Neither was part of the FDA package. Thus, HARMONY 1, 1-bis, 2, and 4 were all failures. The only trials that \"worked \" were CTP - where they had to find 21 patients in Russia - and Harmony 3, an absurd open-label naturalistic trial that we shall get to. We show below the only available crumbs for HARMONY 2, from a table in the EMA review and ClinicalTrials.gov. The trial planned to enroll 40 patients but was halted midway, in a failed attempt to re-do HARMONY 1, with modafinil as an add-on to pitolisant.",
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      "text": "Efficacy and Safety Study of BF2.649 and BF2.649 Add on Modafinil on Cataplexy in Patients With Narcolespy (Harmony2)",
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      "text": "Source: EMA review and ClinicalTrials.gov",
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      "text": "EMA review table for HARMONY II trial details",
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