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  "documentTitle": "Harmony Biosciences (HRMY)",
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  "notes": "This slide presents raw clinical case data from the FDA FAERS database to support a hypothesis about drug interactions.",
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      "text": "Fifteen days after the first dose of pitolisant (4.5mg – a fraction of the labeled dose of 35.6mg), a 62-year old female patient was hospitalized with a “life-threatening” pulmonary embolism.",
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      "text": "Fifteen days after the first dose of pitolisant (4.5mg – a fraction of the labeled dose of 35.6mg), a 62-year old female patient was hospitalized with a “life-threatening” pulmonary embolism. Pitolisant was discontinued and the embolism resolved within 13 days. Patient was concomitantly on fluvoxamine, an SSRI which is a potent CYP2D6 inhibitor. As we note in a previous section, drug-drug interactions with CYP2D6 inhibitors can lead plasma levels of pitolisant to spike.",
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      "text": "Case ID: 21370166. First dose of aripiprazole and 15 days after the first dose of Wakix, the patient experienced pulmonary embolism...",
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      "text": "Event/Problem Narrative: This initial spontaneous report was reported by the health authority European Medicines Agency (EMA)...",
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      "text": "Source: FDA FAERS – FOIA Case Report Information",
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      "text": "Case ID: 21370166, Event date: July 2022",
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