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  "documentTitle": "Harmony Biosciences (HRMY)",
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  "authorName": "Scorpion Capital",
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  "presentationDate": "2023-03-28 00:00:00",
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  "notes": "The slide highlights a potential contradiction between marketing claims of 'no dependency' and reported withdrawal symptoms.",
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      "text": "Other events include spontaneous abortion and withdrawal symptoms – which we find interesting as the drug is marketed as having no dependency issues whatsoever.",
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      "text": "Serious adverse event reports which contain the following symptoms or combinations of symptoms: Psychotic disorder; bipolar disorder; mania; hypomania; screaming; aggression; schizophrenia; suicidal ideation; hallucinations (28); Anaphylactic reaction/swollen tongue (4); Splenic infarction (4); Inflammation/pneumonia (1); Tardive dyskinesia (1); Spontaneous abortion (1); Vasospasm (1); Serotonin syndrome (1); Withdrawal symptoms (2)",
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      "text": "The most prevalent serious adverse event reports are psychiatric or neurological, which isn’t surprising as the H3 receptor is predominantly expressed in the central nervous system. We counted 28 that mentioned some combination of psychosis or psychotic disorder, bipolar disorder, mania, screaming/aggression, schizophrenia, suicidal ideation, and/or hallucinations – with the event reports frequently mentioning the outcome as hospitalization. We note four that mention anaphylactic reaction and/or swollen tongue, and four that indicate splenic infarction, which we speculate could be related to the phospholipidosis or hypereosinophilia issue. Other events include spontaneous abortion and withdrawal symptoms – which we find interesting as the drug is marketed as having no dependency issues whatsoever.",
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      "text": "Source: Scorpion Capital analysis and estimates based on FDA FAERS database for Wakix; pitolisant; pitolisant hydrochloride",
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