{
  "docId": "019dd923-622c-750b-8b9a-21918ac10c17",
  "docSlug": "f3db2294dcf9",
  "documentTitle": "Harmony Biosciences (HRMY)",
  "authorId": "58_Scorpion_Capital",
  "authorName": "Scorpion Capital",
  "documentKindSlug": "research-note",
  "documentKindLabel": "Research note",
  "sourceTypeSlug": "short_seller",
  "sourceTypeLabel": "Short seller",
  "presentationDate": "2023-03-28 00:00:00",
  "orientation": "landscape",
  "aspectRatio": 1.3333334,
  "pageNumber": 176,
  "pageCount": 366,
  "prevPage": 175,
  "nextPage": 177,
  "slideType": "other",
  "function": "analyze_data",
  "density": "balanced",
  "nDataPoints": 10,
  "notes": "The slide highlights specific medical conditions and counts of adverse event reports from the FDA FAERS database.",
  "elementsJson": [
    "paragraph",
    "bullet_list",
    "footnote"
  ],
  "metadataConfidence": 0.9,
  "imagePath": null,
  "slideHref": "/slides/019dd923-622c-750b-8b9a-21918ac10c17/176",
  "deckHref": "/decks/019dd923-622c-750b-8b9a-21918ac10c17",
  "deckJsonHref": "/decks/019dd923-622c-750b-8b9a-21918ac10c17.json",
  "deckAnchorHref": "/decks/019dd923-622c-750b-8b9a-21918ac10c17#slide-176",
  "components": [
    {
      "bbox": null,
      "kind": "callout",
      "text": "We speculate that the embolisms may be related to pitolisant’s phospholipidosis liability and/or its potential to cause hypereosinophilic syndrome.",
      "attrs": null,
      "subkind": null,
      "toolName": "Visual emphasis",
      "toolSlug": "visual-emphasis",
      "confidence": null,
      "componentId": "019dd953-64d0-7099-9cd7-cdd5a6077d56",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.25,
        "w": 0.47,
        "x": 0.07,
        "y": 0.41
      },
      "kind": "list",
      "text": "Serious adverse event reports which contain the following symptoms or combinations of symptoms\nAcute kidney injury (1)\nHepatic enzyme elevation/pulmonary embolism (1)\nAbnormal hepatic function/pericarditis (1)\nHepatic cytolysis (2)\nAcute hepatitis (1)\nPulmonary embolism (4)",
      "attrs": null,
      "subkind": "bullet",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "5feb3b33-98e3-4616-9d51-e936456f9799",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.35,
        "w": 0.86,
        "x": 0.07,
        "y": 0.07
      },
      "kind": "paragraph",
      "text": "In addition to serious adverse event reports with cardiac symptoms, we note reports of kidney, liver, or pulmonary-related events that were life-threatening and/or required hospitalization: acute kidney injury (42-year old hospitalized with kidney failure); hepatic enzyme elevation; abnormal hepatic function; two reports of hepatic cytolysis, both relatively young patients (37 and 45 years old); and acute hepatitis (18-year old). Pulmonary embolism is mentioned in four reports, and in a fifth in combination with hepatic enzyme elevation. We speculate that the embolisms may be related to pitolisant’s phospholipidosis liability and/or its potential to cause hypereosinophilic syndrome.",
      "attrs": null,
      "subkind": "paragraph",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "95749430-43c3-4b21-b926-3b0e8691b9b7",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.03,
        "w": 0.62,
        "x": 0.07,
        "y": 0.95
      },
      "kind": "source-note",
      "text": "Source: Scorpion Capital analysis and estimates based on FDA FAERS database for Wakix; pitolisant; pitolisant hydrochloride",
      "attrs": null,
      "subkind": null,
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "baa0ed4a-9a6c-4952-9b3f-cde6965f868d",
      "frameworkName": null,
      "frameworkSlug": null
    }
  ],
  "metrics": [],
  "tools": [],
  "frameworks": [],
  "arcBeats": [],
  "loops": [],
  "imagePathAlt": null,
  "thumbSrc": null,
  "thumbSrcAlt": null,
  "locked": true
}