{
  "docId": "019dd923-622c-750b-8b9a-21918ac10c17",
  "docSlug": "f3db2294dcf9",
  "documentTitle": "Harmony Biosciences (HRMY)",
  "authorId": "58_Scorpion_Capital",
  "authorName": "Scorpion Capital",
  "documentKindSlug": "research-note",
  "documentKindLabel": "Research note",
  "sourceTypeSlug": "short_seller",
  "sourceTypeLabel": "Short seller",
  "presentationDate": "2023-03-28 00:00:00",
  "orientation": "landscape",
  "aspectRatio": 1.3333334,
  "pageNumber": 174,
  "pageCount": 366,
  "prevPage": 173,
  "nextPage": 175,
  "slideType": "expose_contradiction",
  "function": "expose_contradiction",
  "density": "dense",
  "nDataPoints": 25,
  "notes": "The slide argues that reporting lags or manipulation by Harmony Biosciences obscures the true number of adverse events.",
  "elementsJson": [
    "paragraph",
    "data_table",
    "bar_chart_horizontal",
    "footnote"
  ],
  "metadataConfidence": 1,
  "imagePath": null,
  "slideHref": "/slides/019dd923-622c-750b-8b9a-21918ac10c17/174",
  "deckHref": "/decks/019dd923-622c-750b-8b9a-21918ac10c17",
  "deckJsonHref": "/decks/019dd923-622c-750b-8b9a-21918ac10c17.json",
  "deckAnchorHref": "/decks/019dd923-622c-750b-8b9a-21918ac10c17#slide-174",
  "components": [
    {
      "bbox": null,
      "kind": "callout",
      "text": "We note 64 respiratory/thoracic and 26 cardiac reports, which are particularly of note given evidence of pitolisant’s cardiotoxicity and the cardiopulmonary-nature of most of the fatalities during clinical trials.",
      "attrs": null,
      "subkind": null,
      "toolName": "Visual emphasis",
      "toolSlug": "visual-emphasis",
      "confidence": null,
      "componentId": "019dd953-64d0-7099-9cd7-22f56bff6713",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.25,
        "w": 0.5,
        "x": 0.43,
        "y": 0.44
      },
      "kind": "chart",
      "text": "Case Count by Received Year",
      "attrs": null,
      "subkind": "bar-horizontal",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "979373c4-0ca4-4cc6-bb2e-61e5b79fedb6",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": null,
      "kind": "metric",
      "text": "Adverse Event Reports: 612",
      "attrs": null,
      "subkind": "primary",
      "toolName": "Quantification",
      "toolSlug": "quantification",
      "confidence": null,
      "componentId": "019dd953-64d0-7099-9cd7-26f4fb690228",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.32,
        "w": 0.86,
        "x": 0.07,
        "y": 0.07
      },
      "kind": "paragraph",
      "text": "The FDA Adverse Events Reporting System (FAERS) indicates 612 case reports for pitolisant/Wakix through Dec 31, 2022, almost all from 2019 to 2022, despite the relatively small number of patients who have taken the drug. We think lags in the database and/or reporting games by Harmony mean the number of actual case reports in the last two years is several-fold higher, as we shall explain. Of these, 80% (~470 cases) are nervous system and psychiatric and 130 are gastrointestinal. We note 64 respiratory/thoracic and 26 cardiac reports, which are particularly of note given evidence of pitolisant's cardiotoxicity and the cardiopulmonary-nature of most of the fatalities during clinical trials.",
      "attrs": null,
      "subkind": "paragraph",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "43123d0c-3366-4a99-a25e-69b1b93a197a",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.03,
        "w": 0.86,
        "x": 0.07,
        "y": 0.4
      },
      "kind": "source-note",
      "text": "Data and charts from FDA FAERS for search terms Wakix/pitolisant/pitolisant hydrochloride",
      "attrs": null,
      "subkind": null,
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "ae52af52-aa97-4250-a94d-90a816bb3f2c",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.02,
        "w": 0.4,
        "x": 0.07,
        "y": 0.94
      },
      "kind": "source-note",
      "text": "Source: FDA FAERS database for Wakix; pitolisant; pitolisant hydrochloride",
      "attrs": null,
      "subkind": null,
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "f4a846bc-3ec2-4e07-be24-d719e659e623",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.48,
        "w": 0.35,
        "x": 0.07,
        "y": 0.44
      },
      "kind": "table",
      "text": "Reaction Group table with 20 rows of case counts",
      "attrs": null,
      "subkind": "data",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "efb91707-f0e5-44e4-be30-58b1e0b3435e",
      "frameworkName": null,
      "frameworkSlug": null
    }
  ],
  "metrics": [],
  "tools": [],
  "frameworks": [],
  "arcBeats": [],
  "loops": [],
  "imagePathAlt": null,
  "thumbSrc": null,
  "thumbSrcAlt": null,
  "locked": true
}