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  "documentTitle": "Harmony Biosciences (HRMY)",
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  "authorName": "Scorpion Capital",
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  "notes": "The slide uses a combination of original analysis and cited medical literature to challenge the transparency of clinical trial reporting.",
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      "text": "Lungs are a frequent target of hypereosinophilia – example papers",
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      "text": "Hypereosinophilic syndrome “may intrinsically cause tissue and organ damage”",
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      "text": "Furthermore, we could locate no mention of hypereosinophilia in any of Bioprojet’s or Harmony’s papers or trials, so we assume they covered it up and/or just stopped measuring it in later studies.",
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      "text": "Lung involvement in hypereosinophilic syndromes\nHypereosinophilic syndromes and lung involvement",
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      "text": "The brief EMA mention of hyper-eosinophilia contains no information as to how abnormal the eosinophil count was or whether a tissue biopsy accompanied the blood panel to measure tissue infiltration – “hypereosinophilia is often but not uniformly associated with eosinophilic infiltration of tissues that can potentially lead to irreversible, life-threatening organ damage.” Furthermore, we could locate no mention of hypereosinophilia in any of Bioprojet’s or Harmony’s papers or trials, so we assume they covered it up and/or just stopped measuring it in later studies. Eosinophils are white blood cells that are part of the immune system, typically associated with inflammation. The clinical literature indicates that the lungs are a common target of hypereosinophilic syndrome, and that cardiopulmonary abnormality manifests in >70% of patients.",
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      "text": "Markedly increased blood eosinophilia, ≥1.5 × 10⁹/L, whether discovered fortuitously or found with signs and symptoms of associated organ involvement, commands diagnostic evaluation and often therapeutic interventions. This degree of hypereosinophilia is often, but not uniformly, associated with eosinophilic infiltration of tissues that can potentially lead to irreversible, life-threatening organ damage. Initial approaches focus on ascertaining that eosinophilia is not secondary to other",
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      "text": "“hypereosinophilia is often but not uniformly associated with eosinophilic infiltration of tissues that can potentially lead to irreversible, life-threatening organ damage.” — Unattributed medical literature",
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      "text": "Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2902584/; https://www.resmedjournal.com/article/S0954-6111(10)00414-2/fulltext; https://www.ers-education.org/lr/show-details/?idP=254844",
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