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  "documentTitle": "Harmony Biosciences (HRMY)",
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  "authorName": "Scorpion Capital",
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  "presentationDate": "2023-03-28 00:00:00",
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  "notes": "The slide uses a table to contrast initial high-dose trials with subsequent lower-dose trials to imply company knowledge of toxicity.",
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      "text": "Given that the trials with higher doses were flops with all manner of junk statistical and other tricks, as we detail in a later section, the sudden dose reduction dose is telling as companies typically try higher doses to elicit a therapeutic response.",
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      "text": "Given that the trials with higher doses were flops with all manner of junk statistical and other tricks, as we detail in a later section, the sudden dose reduction dose is telling as companies typically try higher doses to elicit a therapeutic response. Bioprojet has run pitolisant trials for every indication under the sun, with no success, and we note that a number of later trials capped the maximum dose at 20 mg.",
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      "text": "Bioprojet appears to have quicky realized the toxicity risk at 40 mg – again, similar to the current dose on the label - as the next studies then tested 10 and 20 mg, and then took it down further to test 5 mg.",
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