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  "documentTitle": "Harmony Biosciences (HRMY)",
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  "authorName": "Scorpion Capital",
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  "notes": "The slide uses a red box to highlight the 'n=17' discrepancy in the source text.",
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      "kind": "callout",
      "text": "Pitolisant pilot study, first published in 2007, indicates massive plasma level variability",
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      "text": "In our opinion, the paper exemplifies what we believe to be a 20+ year pattern of scientific and clinical dishonesty by the inner circle that pop ups repeatedly in Bioprojet’s key papers and trials, all of whom are authors on the paper.",
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      "text": "The paper states that 5 of 22 patients had elevated plasma levels >150 ng/mL but doesn’t state how high it spiked. Yet the paper is written to convey the impression that the average plasma level and range is far lower: “the plasma level average 100.6 + 78.1 ng/mL (n=17).” But note the insertion of “n=17” – in other words, the study had 22 patients, but Bioprojet EXCLUDED the five with plasma levels >150 ng/mL in the calculation, making it impossible to deduce how high it went. In our opinion, the paper exemplifies what we believe to be a 20+ year pattern of scientific and clinical dishonesty by the inner circle that pop ups repeatedly in Bioprojet’s key papers and trials, all of whom are authors on the paper.",
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      "text": "An inverse agonist of the histamine H3 receptor improves wakefulness in narcolepsy: Studies in orexin-/- mice and patients",
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      "text": "We note another red flag in the 2007 pilot study – another statistical trick so cunning that it suggests Bioprojet went to great pains to conceal the danger of elevated plasma levels.",
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      "text": "Tiprolisant dosages were performed at the end of the treatment period with a median sampling time at 3.75 h after the last drug intake. The plasma level average was 100.6±78.1 ng/ml (n=17). Elevated plasma levels (>150 ng/ml) were observed in 5 patients, in some cases related to the experience of adverse events occurring a few hours after drug intake.",
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      "text": "the plasma level average 100.6 + 78.1 ng/mL (n=17) — 2007 Pitolisant pilot study",
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      "text": "Source: https://pubmed.ncbi.nlm.nih.gov/18295497/",
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